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Research ArticleClinical Studies

Reduced Galectin-3 Expression is an Indicator of Unfavorable Prognosis in Gastric Cancer

KOHJI OKADA, TATSUO SHIMURA, TAKETOSHI SUEHIRO, ERITO MOCHIKI and HIROYUKI KUWANO
Anticancer Research March 2006, 26 (2B) 1369-1376;
KOHJI OKADA
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  • For correspondence: okako@med.gunma-u.ac.jp
TATSUO SHIMURA
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TAKETOSHI SUEHIRO
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ERITO MOCHIKI
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HIROYUKI KUWANO
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Abstract

Background: Galectin-3 (gal-3) participates in a variety of biological events, including cell adhesion, proliferation, differentiation and apoptosis. The aim of this study was to determine the relationship of gal-3 expression with clinicopathological findings and prognosis in patients with gastric cancer. Patients and Methods: Gal-3 and Ki-67 expressions were assessed by immunohistochemistry in 115 patients with gastric cancer. PCR-single strand conformation polymorphism (SSCP)-sequence analysis and the levels of gal-3 mRNA were also examined. Results: The present study demonstrated that gal-3 expression was correlated with nodal status, lymphatic invasion, pathological stage and histological parameters. On the other hand, gal-3 expression did not correlate with the expression of Ki-67. Reduced expression of gal-3 was significantly associated with a poor prognosis and multivariate analysis showed that gal-3 expression was an independent prognostic factor. On PCR-SSCP-sequence analysis, 2 single nucleotide polymorphisms (SNPs) were detected in the gal-3 gene, but none showed mutations. Conclusion: Reduced gal-3 expression was associated with lymph node metastasis, advanced stage and tumor differentiation in gastric cancer. Gal-3 expression could be a useful prognostic factor in gastric cancer.

  • Galectin-3
  • SSCP
  • SNP
  • gastric cancer
  • prognosis

Footnotes

  • Received December 27, 2005.
  • Accepted February 8, 2006.
  • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 26 (2B)
Anticancer Research
Vol. 26, Issue 2B
March-April 2006
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Reduced Galectin-3 Expression is an Indicator of Unfavorable Prognosis in Gastric Cancer
KOHJI OKADA, TATSUO SHIMURA, TAKETOSHI SUEHIRO, ERITO MOCHIKI, HIROYUKI KUWANO
Anticancer Research Mar 2006, 26 (2B) 1369-1376;

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Reduced Galectin-3 Expression is an Indicator of Unfavorable Prognosis in Gastric Cancer
KOHJI OKADA, TATSUO SHIMURA, TAKETOSHI SUEHIRO, ERITO MOCHIKI, HIROYUKI KUWANO
Anticancer Research Mar 2006, 26 (2B) 1369-1376;
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