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Research ArticleExperimental Studies

Curcumin Inhibits Cell Migration of Human Colon Cancer Colo 205 Cells through the Inhibition of Nuclear Factor kappa B /p65 and Down-regulates Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expressions

CHIN-CHENG SU, GUANG-WEI CHEN, JAUNG-GENG LIN, LII-TZU WU and JING-GUNG CHUNG
Anticancer Research March 2006, 26 (2A) 1281-1288;
CHIN-CHENG SU
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GUANG-WEI CHEN
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JAUNG-GENG LIN
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LII-TZU WU
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JING-GUNG CHUNG
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  • For correspondence: jgchung@mail.cmu.edu.tw
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Abstract

Curcumin (diferuloylmethane) is a chemical derived from several Curcuma species (turmeric), possessing anti-inflammatory and antioxidant properties and which, thus, may be a potential anticancer drug. However, its mechanism of action is not fully understood. Our previous studies had shown that curcumin induced cytotoxicity, cell cycle arrest and apoptosis in human colon cancer colo 205 cells. In this study, curcumin affected the levels of NF-κB/ p65 in a time-dependent manner but did not affect NF-κB/ p50, based on Western blotting methods. In vitro experiments revealed that curcumin inhibited Cox-2 levels, but promoted those of Cox-1 in colo 205 cells. Curcumin also inhibited MMP-2 levels and promoted MMP-9 levels, but did not affect MMP-7 levels, based on Western blotting assays. These effects were also confirmed by cDNA microarray. Remarkably, curcumin not only exerted its effect on the protein levels of NF-κB, Cox-1 and -2, MMP-2 and -7, but also directly inhibited their mRNA levels. Curcumin was also found to significantly repress the in vitro invasion of colo 205 cells.

  • Curcumin
  • cell migration
  • NF-κB /p65
  • Cox-2
  • MMP-2

Footnotes

  • Received October 21, 2005.
  • Revision received February 2, 2006.
  • Accepted February 8, 2006.
  • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 26 (2A)
Anticancer Research
Vol. 26, Issue 2A
March-April 2006
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Curcumin Inhibits Cell Migration of Human Colon Cancer Colo 205 Cells through the Inhibition of Nuclear Factor kappa B /p65 and Down-regulates Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expressions
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Curcumin Inhibits Cell Migration of Human Colon Cancer Colo 205 Cells through the Inhibition of Nuclear Factor kappa B /p65 and Down-regulates Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expressions
CHIN-CHENG SU, GUANG-WEI CHEN, JAUNG-GENG LIN, LII-TZU WU, JING-GUNG CHUNG
Anticancer Research Mar 2006, 26 (2A) 1281-1288;

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Curcumin Inhibits Cell Migration of Human Colon Cancer Colo 205 Cells through the Inhibition of Nuclear Factor kappa B /p65 and Down-regulates Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expressions
CHIN-CHENG SU, GUANG-WEI CHEN, JAUNG-GENG LIN, LII-TZU WU, JING-GUNG CHUNG
Anticancer Research Mar 2006, 26 (2A) 1281-1288;
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