Abstract
Background: The present study investigated the efficacy of oral doxifluridine (5'-DFUR) by comparing the survival between patients who received 5'-DFUR at 800 mg/body daily for 1 or 3 years after surgery for stage 1, 2 or 3 breast cancer. Patients and Methods: Ninety-two patients were enrolled from January 1995 to December 1997, of whom 87 were eligible. The patients were stratified into pre-menopausal and post-menopausal groups, and then each group was further stratified into 1-year or 3-year administration groups. All patients were given endocrine therapy, with gosereline acetate (3.6 mg/body, monthly) for the pre-menopausal patients and tamoxifen (20 mg/day, daily) for the post-menopausal patients for 3 years. Results: The median follow-up duration was 9.5 years. Although no differences were found in the overall or disease-free survivals between the administration groups, subset analysis demonstrated that, in the pre-menopausal patients, the 3-year administration group showed a significantly higher overall survival rate than the 1-year administration group, but not in post-menopausal patients. A multivariate analysis also indicated that the administration duration of 5'-DFUR was a significant factor for disease-free survival. Conclusion: The present study supports the usefulness of 5'-DFUR for adjuvant chemotherapy against breast cancer, especially for pre-menopausal patients; however, further clinical study with a much larger sample size is necessary to reach a conclusive result.
Footnotes
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↵* The investigators and their affiliations are summarized in Table I.
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Abbreviations: ACT, adjuvant chemotherapy; DFS, disease-free survival; 5'-DFUR, doxifluridine; ER, estrogen receptor; 5-FU, 5-fluorouracil; GA, gosereline acetate; OS, overall survival; RR, response rate; TAM, tamoxifen; UFT, tegafur plus uracil.
- Received August 18, 2005.
- Accepted September 29, 2005.
- Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved