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Research ArticleExperimental Studies

Conjugated Linoleic Acid (CLA) Up-regulates the Estrogen-regulated Cancer Suppressor Gene, Protein Tyrosine Phosphatase γ (PTPγ), in Human Breast Cells

LI-SHU WANG, YI-WEN HUANG, YASURO SUGIMOTO, SULING LIU, HSIANG-LIN CHANG, WEIPING YE, SHERRY SHU and YOUNG C. LIN
Anticancer Research January 2006, 26 (1A) 27-34;
LI-SHU WANG
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YI-WEN HUANG
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YASURO SUGIMOTO
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SULING LIU
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HSIANG-LIN CHANG
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WEIPING YE
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SHERRY SHU
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YOUNG C. LIN
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  • For correspondence: lin.15@osu.edu
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Abstract

Background: Conjugated linoleic acid (CLA), a naturally occurring compound found in ruminants products, has been shown to possess anticancer properties in vivo and in vitro. There are several CLA isomers in ruminant-produced foods, among which t10,c12-CLA and c9,t11-CLA are the most potent. Protein tyrosine phosphatase γ (PTPγ) has been implicated as a tumor suppressor gene in kidney and lung cancers. Our previous results indicated that estradiol-17β (E2)-induced suppression of PTPγ may play a role in mammary tumorigenesis. Materials and Methods: The effects of t10,c12-CLA and c9,t11-CLA on PTPγ mRNA expression in human breast epithelial cells and stromal cells, isolated from surgical specimens of mammoplasty and breast cancer patients, were detected and quantified by RT-PCR. Results: The PTPγ mRNA expression was lower in cancer than in normal breast cells. Both t10,c12-CLA and c9,t11-CLA significantly (p<0.05) increased the PTPγ mRNA levels in primary cultured normal breast epithelial cells, normal breast stromal cells and breast cancer epithelial cells, but not in breast cancer stromal cells. t10,c12-CLA appeared to be the most active isomer in estrogen receptor α(ERα)-positive human breast cancer epithelial cells. Conclusion: The results indicate that dietary CLA might serve as a chemo-preventive and chemo-therapeutic agent in human breast cancers by up-regulating the estrogen-regulated tumor suppressor gene, PTPγ expression.

  • Breast cancer cells
  • CLA
  • PTPγ

Footnotes

    • Received August 16, 2005.
    • Accepted October 10, 2005.
    • Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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    Anticancer Research: 26 (1A)
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    January-February 2006
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    Conjugated Linoleic Acid (CLA) Up-regulates the Estrogen-regulated Cancer Suppressor Gene, Protein Tyrosine Phosphatase γ (PTPγ), in Human Breast Cells
    LI-SHU WANG, YI-WEN HUANG, YASURO SUGIMOTO, SULING LIU, HSIANG-LIN CHANG, WEIPING YE, SHERRY SHU, YOUNG C. LIN
    Anticancer Research Jan 2006, 26 (1A) 27-34;

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    Conjugated Linoleic Acid (CLA) Up-regulates the Estrogen-regulated Cancer Suppressor Gene, Protein Tyrosine Phosphatase γ (PTPγ), in Human Breast Cells
    LI-SHU WANG, YI-WEN HUANG, YASURO SUGIMOTO, SULING LIU, HSIANG-LIN CHANG, WEIPING YE, SHERRY SHU, YOUNG C. LIN
    Anticancer Research Jan 2006, 26 (1A) 27-34;
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