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Research ArticleClinical Studies

Chemosensitivity Testing of a Novel Platinum Analog, Nedaplatin (254-S), in Human Gynecological Carcinomas: a Comparison with Cisplatin

MASAFUMI KOSHIYAMA, MASANORI KINEZAKI, TAKAFUMI UCHIDA and MASAHIRO SUMITOMO
Anticancer Research November 2005, 25 (6C) 4499-4502;
MASAFUMI KOSHIYAMA
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  • For correspondence: koshiyamam@nifty.com
MASANORI KINEZAKI
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TAKAFUMI UCHIDA
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MASAHIRO SUMITOMO
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Abstract

Background: The tetrazolium dye (MTT) assay is useful for predicting chemosensitivity. Materials and Methods: Using the MTT assay, an in vitro chemosensitivity test was designed for nedaplatin (cis-diammine glycolato platinum; 254-S) and the results were compared with the sensitivity to cisplatin in 137 resected gynecological carcinomas. Results: The mean tumor inhibition rate [I.R.; %] for nedaplatin was equal or superior to cisplatin in 15 cervical [70.7% vs. 63.9%], 65 ovarian [61.7% vs. 54.8%] and 57 endometrial carcinomas [52.1% vs. 47.7%]. In ovarian carcinomas, the I.R.s for nedaplatin were significantly higher than cisplatin in poorly-differentiated, serous and endometrioid adenocarcinomas [80.7% vs. 56.4% (p<0.05), 77.0% vs. 64.9% (p<0.01), and 68.2% vs. 54.6% (p<0.05), respectively]. Conclusion: Our data suggest that nedaplatin has equivalent or superior antitumor activity to cisplatin in cervical, ovarian and endometrial carcinomas. In particular, nedaplatin showed a siginificantly better antitumor activity among the histological subtypes of ovarian carcinomas.

  • Nedaplatin
  • MTT assay
  • ovarian carcinoma
  • cervical carcinoma
  • endometrial carcinoma

Footnotes

  • Received June 10, 2005.
  • Accepted July 20, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (6C)
Anticancer Research
Vol. 25, Issue 6C
1 Nov 2005
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Chemosensitivity Testing of a Novel Platinum Analog, Nedaplatin (254-S), in Human Gynecological Carcinomas: a Comparison with Cisplatin
MASAFUMI KOSHIYAMA, MASANORI KINEZAKI, TAKAFUMI UCHIDA, MASAHIRO SUMITOMO
Anticancer Research Nov 2005, 25 (6C) 4499-4502;

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Chemosensitivity Testing of a Novel Platinum Analog, Nedaplatin (254-S), in Human Gynecological Carcinomas: a Comparison with Cisplatin
MASAFUMI KOSHIYAMA, MASANORI KINEZAKI, TAKAFUMI UCHIDA, MASAHIRO SUMITOMO
Anticancer Research Nov 2005, 25 (6C) 4499-4502;
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