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Research ArticleClinical Studies

P16INK4a Correlates to Human Papillomavirus Presence, Response to Radiotherapy and Clinical Outcome in Tonsillar Carcinoma

HANNA MELLIN DAHLSTRAND, DAVID LINDQUIST, LINDA BJÖRNESTAL, ANN OHLSSON, TINA DALIANIS, EVA MUNCK-WIKLAND and GÖRAN ELMBERGER
Anticancer Research November 2005, 25 (6C) 4375-4383;
HANNA MELLIN DAHLSTRAND
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  • For correspondence: hanna.dahlstrand@karolinska.se
DAVID LINDQUIST
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LINDA BJÖRNESTAL
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ANN OHLSSON
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TINA DALIANIS
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EVA MUNCK-WIKLAND
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GÖRAN ELMBERGER
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Abstract

Background: Human papillomavirus (HPV) in tonsillar carcinoma is correlated with favourable clinical outcome. Here, p16INK4A, in situ HPV DNA hybridisation (ISH) and HPV L1 capsid detection were evaluated in tonsillar carcinoma to predict the response to radiotherapy (RT) and prognosis. Materials and Methods: Fifty-one pre-treatment paraffin-embedded tonsillar cancer biopsies were analysed. Immunohistochemistry (IHC) was used for p16INK4A and HPV L1 capsid analysis and PCR and ISH for HPV detection. Results: High-risk HPV DNA was detected by PCR in 49% of the tumours. P16INK4a staining was correlated to HPV. In the high-grade p16INK4a staining group, 94% had a complete RT response. High p16INK4a staining as well as the HPV PCR-positive cases had a favourable prognosis. HPV DNA ISH and L1 IHC could not predict RT response or clinical outcome. Conclusion: P16INK4a overexpression was correlated to HPV in tonsillar carcinoma and is useful for predicting RT response and prognosis in tonsillar carcinoma patients.

  • HPV
  • tonsillar carcinoma
  • p16
  • radiotherapy
  • L1 capsid
  • HPV ISH
  • prognosis

Footnotes

  • Received June 29, 2005.
  • Accepted July 22, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (6C)
Anticancer Research
Vol. 25, Issue 6C
1 Nov 2005
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P16INK4a Correlates to Human Papillomavirus Presence, Response to Radiotherapy and Clinical Outcome in Tonsillar Carcinoma
HANNA MELLIN DAHLSTRAND, DAVID LINDQUIST, LINDA BJÖRNESTAL, ANN OHLSSON, TINA DALIANIS, EVA MUNCK-WIKLAND, GÖRAN ELMBERGER
Anticancer Research Nov 2005, 25 (6C) 4375-4383;

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P16INK4a Correlates to Human Papillomavirus Presence, Response to Radiotherapy and Clinical Outcome in Tonsillar Carcinoma
HANNA MELLIN DAHLSTRAND, DAVID LINDQUIST, LINDA BJÖRNESTAL, ANN OHLSSON, TINA DALIANIS, EVA MUNCK-WIKLAND, GÖRAN ELMBERGER
Anticancer Research Nov 2005, 25 (6C) 4375-4383;
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