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Research ArticleClinical Studies

Galectin-3 Expression is a Potent Prognostic Marker in Colorectal Cancer

KAZUYA ENDO, SHUNJI KOHNOE, EIJI TSUJITA, AKIHIRO WATANABE, HIDEAKI NAKASHIMA, HIDEO BABA and YOSHIHIKO MAEHARA
Anticancer Research July 2005, 25 (4) 3117-3121;
KAZUYA ENDO
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  • For correspondence: kendo@munakata-med-hp.gr.jp
SHUNJI KOHNOE
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EIJI TSUJITA
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AKIHIRO WATANABE
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HIDEAKI NAKASHIMA
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HIDEO BABA
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YOSHIHIKO MAEHARA
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Abstract

Background: Galectin-3 is a β-galactoside-binding protein whose expression has been correlated with progression and metastasis in colon cancer. It is expressed at elevated levels in a variety of neoplastic cells. The current study was designed to investigate, by clinicopathological analysis, the relationship between prognosis and galectin-3 expression, in colorectal cancer. Patients and Methods: Galectin-3 expression was evaluated using immunohistochemical staining in 121 consecutive patients with colorectal cancer. The relationship between galectin-3 expression and clinicopathological factors was analyzed. Results: Galectin-3-positive expression was detected in 79 patients (65%). The incidence of lymph node and distant metastasis in galectin 3-positive cancer was significantly higher than that in galectin-3-negative cases (p=0.0007 and p=0.014, respectively). Furthermore, cancers with galectin-3-positive expression revealed frequent venous invasion (p=0.005) and lymphatic permeation(p=0.041), larger size (p=0.016) and deeper invasion to wall(p=0.01) than in galectin-3-negative cases. While univariate analysis showed that survival in patients with galectin-3-positive expression was significantly poorer than in galectin-3-negative cases (p=0.0027), galectin-3 expression was a prognostic factor independent of Dukes' stage and lymph node metastasis by multivariate analysis. Conclusion: We propose that galectin-3 expression is an independent factor for prognosis in colorectal cancer.

  • Colorectal cancer
  • galectin-3 expression
  • prognosis
  • immunohistochemistry

Footnotes

    • Received January 18, 2005.
    • Accepted May 12, 2005.
    • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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    Anticancer Research: 25 (4)
    Anticancer Research
    Vol. 25, Issue 4
    1 Jul 2005
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    Galectin-3 Expression is a Potent Prognostic Marker in Colorectal Cancer
    KAZUYA ENDO, SHUNJI KOHNOE, EIJI TSUJITA, AKIHIRO WATANABE, HIDEAKI NAKASHIMA, HIDEO BABA, YOSHIHIKO MAEHARA
    Anticancer Research Jul 2005, 25 (4) 3117-3121;

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    Galectin-3 Expression is a Potent Prognostic Marker in Colorectal Cancer
    KAZUYA ENDO, SHUNJI KOHNOE, EIJI TSUJITA, AKIHIRO WATANABE, HIDEAKI NAKASHIMA, HIDEO BABA, YOSHIHIKO MAEHARA
    Anticancer Research Jul 2005, 25 (4) 3117-3121;
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