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Review ArticleClinical Studies

Telomere Attrition as Ageing Biomarker

SOFIE BEKAERT, TIM DE MEYER and PATRICK VAN OOSTVELDT
Anticancer Research July 2005, 25 (4) 3011-3021;
SOFIE BEKAERT
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  • For correspondence: sofie.bekaert@UGent.be
TIM DE MEYER
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PATRICK VAN OOSTVELDT
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Abstract

Telomeres, the tandem-repeated hexamers at the termini of mammalian chromosomes, form protective complexes in association with specific proteins that together with telomerase, a specialised telomere-synthesizing enzyme, regulate telomere length. Telomere shortening is associated with cellular senescence and is implicated in tumorigenesis and cancer. Hence, mean telomere length has emerged as a replicative clock within each population of cells and the tissues and organs they build up in vitro and, consequently, as a biomarker for biological ageing in vivo. Chronological ageing per se does not parallel biological ageing, yet accurate and reliable biomarkers are lacking to distinguish between them. The question remains as to whether telomere dynamics is a determinant or merely a predictor of human biological age over and above chronological ageing. Although several reports have suggested a link between telomere attrition and ageing phenotypes and disorders, both reference values and a complete set of determinants are missing. Within this review, current evidence and knowledge on telomere length and telomere erosion rates reported, are summarised.

  • Telomere length
  • telomere shortening
  • ageing
  • review

Footnotes

  • Received March 7, 2005.
  • Accepted May 23, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Telomere Attrition as Ageing Biomarker
SOFIE BEKAERT, TIM DE MEYER, PATRICK VAN OOSTVELDT
Anticancer Research Jul 2005, 25 (4) 3011-3021;

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Telomere Attrition as Ageing Biomarker
SOFIE BEKAERT, TIM DE MEYER, PATRICK VAN OOSTVELDT
Anticancer Research Jul 2005, 25 (4) 3011-3021;
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