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Research ArticleClinical Studies

AFP-producing Hepatoid Adenocarcinoma in Association with Barrett's Esophagus with Multiple Liver Metastasis Responding to Paclitaxel/CDDP: A Case Report

NATSUKO CHIBA, TAKASHI YOSHIOKA, MASATO SAKAYORI, YOSHIKI MIKAMI, SHUKICHI MIYAZAKI, SHOKO AKIYAMA, KAZUNORI OTSUKA, GENGO YAMAURA, HIROYUKI SHIBATA, SYUNSUKE KATO, SATOSHI KATO and CHIKASHI ISHIOKA
Anticancer Research July 2005, 25 (4) 2965-2968;
NATSUKO CHIBA
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TAKASHI YOSHIOKA
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MASATO SAKAYORI
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YOSHIKI MIKAMI
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SHUKICHI MIYAZAKI
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SHOKO AKIYAMA
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KAZUNORI OTSUKA
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GENGO YAMAURA
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HIROYUKI SHIBATA
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SYUNSUKE KATO
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SATOSHI KATO
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CHIKASHI ISHIOKA
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Abstract

A case of alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma in association with Barrett's esophagus with multiple liver metastases, responding to chemotherapy, is reported. A 47-year-old man was admitted to our hospital with abdominal pain after subtotal esophagectomy for an esophageal adenocarcinoma in association with Barrett's esophagus, and was diagnosed as having multiple liver tumors. Most tumor markers were normal, but the serum AFP level was markedly elevated. Dynamic computed tomography and ferumoxide enhanced magnetic resonance imaging did not provide evidence of any primary hepatocellular carcinoma. Since microscopic examination of the resected tumor showed a poorly-differentiated adenocarcinoma with hepatoid features displaying AFP-immunoreactivity, the liver tumors were thus considered to be metastatic deposits. Surgery was not feasible so chemotherapeutic agents were tried, and the combination of paclitaxel (TXL) and cisplatin (CDDP) gave a partial response and good control for a period. This is the first report, to our knowledge, of effective chemotherapy for liver metastases from an AFP-producing hepatoid adenocarcinoma of the esophagus.

  • Hepatoid adenocarcinoma
  • AFP-producing Barrett's esophageal cancer
  • liver metastasis
  • paclitaxel
  • cisplatin

Footnotes

  • Received January 21, 2005.
  • Accepted April 20, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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AFP-producing Hepatoid Adenocarcinoma in Association with Barrett's Esophagus with Multiple Liver Metastasis Responding to Paclitaxel/CDDP: A Case Report
NATSUKO CHIBA, TAKASHI YOSHIOKA, MASATO SAKAYORI, YOSHIKI MIKAMI, SHUKICHI MIYAZAKI, SHOKO AKIYAMA, KAZUNORI OTSUKA, GENGO YAMAURA, HIROYUKI SHIBATA, SYUNSUKE KATO, SATOSHI KATO, CHIKASHI ISHIOKA
Anticancer Research Jul 2005, 25 (4) 2965-2968;

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AFP-producing Hepatoid Adenocarcinoma in Association with Barrett's Esophagus with Multiple Liver Metastasis Responding to Paclitaxel/CDDP: A Case Report
NATSUKO CHIBA, TAKASHI YOSHIOKA, MASATO SAKAYORI, YOSHIKI MIKAMI, SHUKICHI MIYAZAKI, SHOKO AKIYAMA, KAZUNORI OTSUKA, GENGO YAMAURA, HIROYUKI SHIBATA, SYUNSUKE KATO, SATOSHI KATO, CHIKASHI ISHIOKA
Anticancer Research Jul 2005, 25 (4) 2965-2968;
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