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Research ArticleClinical Studies

Postradiation Malignant Fibrous Histiocytoma and Osteosarcoma of a Patient with High Telomerase Activities

TOSHIHIRO MATSUO, TAKASHI SUGITA, SHOJI SHIMOSE, TADAHIKO KUBO, YUJI YASUNAGA, EISO HIYAMA and MITSUO OCHI
Anticancer Research July 2005, 25 (4) 2951-2955;
TOSHIHIRO MATSUO
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  • For correspondence: tmatsuo@hiroshima-u.ac.jp
TAKASHI SUGITA
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SHOJI SHIMOSE
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TADAHIKO KUBO
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YUJI YASUNAGA
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EISO HIYAMA
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MITSUO OCHI
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Abstract

Background: An extremely rare case of postradiation malignant fibrous histiocytoma (MFH) and osteosarcoma (OS) secondary to radiation therapy for leukemia-related osteolytic lesions is presented. In addition, the telomere biology of these tumors was investigated. Case Report: A 14-year-old boy was diagnosed with acute lymphocytic leukemia. The right tibia was irradiated at a total dose of 60 Gy, and the left tibia was irradiated at a total dose of 40 Gy. The left tibia developed MFH and the right tibia developed OS. Results: Telomere reduction (MFH 70.2, OS 70.0%) and high telomerase activities (MFH 12.1, OS 17.7 TPG) were observed. These results reflect an aggressive feature of postradiation sarcomas. Conclusion: Prognosis for patients diagnosed with postradiation sarcoma is poor due to its aggressiveness. However, even if sarcoma occurs after irradiation in more than two fields in a single patient, improvements in prognosis are anticipated with appropriate chemotherapies and wide resection.

  • Postradiation sarcoma
  • malignant fibrous histiocytoma
  • osteosarcoma
  • telomerase activity
  • telomere length

Footnotes

  • Received February 17, 2005.
  • Accepted May 17, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Postradiation Malignant Fibrous Histiocytoma and Osteosarcoma of a Patient with High Telomerase Activities
TOSHIHIRO MATSUO, TAKASHI SUGITA, SHOJI SHIMOSE, TADAHIKO KUBO, YUJI YASUNAGA, EISO HIYAMA, MITSUO OCHI
Anticancer Research Jul 2005, 25 (4) 2951-2955;

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Postradiation Malignant Fibrous Histiocytoma and Osteosarcoma of a Patient with High Telomerase Activities
TOSHIHIRO MATSUO, TAKASHI SUGITA, SHOJI SHIMOSE, TADAHIKO KUBO, YUJI YASUNAGA, EISO HIYAMA, MITSUO OCHI
Anticancer Research Jul 2005, 25 (4) 2951-2955;
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