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Research ArticleExperimental Studies

Effect of Fraxiparine and Heparin on Experimental Tumor Metastasis in Mice

BÉLA SZENDE, SANDOR PAKU, GERGELY RACZ and LASZLO KOPPER
Anticancer Research July 2005, 25 (4) 2869-2872;
BÉLA SZENDE
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  • For correspondence: bszende@korb1.sote.hu
SANDOR PAKU
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GERGELY RACZ
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LASZLO KOPPER
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Abstract

Background: Low molecular weight heparins (LMWH) have become increasingly important in anticoagulant therapy. Antitumor and antimetastatic activity of heparin and LMWH-s have also been reported. Materials and Methods: Fraxiparine, a new modified LMW-H, was tested for antimetastatic effect using 3LL-HH intravenous, B16 intra-foot pad and 3LL-HH intrasplenic models in C57 Bl/6 mice. The dose of Fraxiparine was 38, 57 and 172 IU/kg, respectively. Heparin (100 IU/kg) was used as a positive control. Both pre-treatment (starting 6 hours before tumor inoculation) and post-treatment (starting 24 hours after tumor inoculation), followed by daily injections, were applied in the intra-foot pad and intrasplenic models. In the intravenous model, only a single dose was administered one hour after tumor cell injection. Results: Fraxiparine at the dose of 57 IU/kg was significantly antimetastatic in the intravenous model. Continuous treatment, starting 6 hours before tumor inoculation, with 173 IU/kg Fraxiparine resulted in a strong inhibition of lung metastases in the intra-foot pad model, but was ineffective in the intrasplenic model. Heparin did not influence the metastasis number in any of the metastasis models. Conclusion: These data may be of importance in the anticoagulant treatment of human cancer patients.

  • Heparin
  • Fraxiparine
  • metastasis
  • mouse
  • tumors

Footnotes

  • Received January 25, 2005.
  • Accepted April 14, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Effect of Fraxiparine and Heparin on Experimental Tumor Metastasis in Mice
BÉLA SZENDE, SANDOR PAKU, GERGELY RACZ, LASZLO KOPPER
Anticancer Research Jul 2005, 25 (4) 2869-2872;

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Effect of Fraxiparine and Heparin on Experimental Tumor Metastasis in Mice
BÉLA SZENDE, SANDOR PAKU, GERGELY RACZ, LASZLO KOPPER
Anticancer Research Jul 2005, 25 (4) 2869-2872;
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