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Research ArticleExperimental Studies

In Vitro Anticancer Activity of Cyanidin-3-O-β-Glucopyranoside: Effects on Transformed and Non-transformed T Lymphocytes

CARMELA FIMOGNARI, FAUSTO BERTI, MICHAEL NÜSSE, GIORGIO CANTELLI-FORTI and PATRIZIA HRELIA
Anticancer Research July 2005, 25 (4) 2837-2840;
CARMELA FIMOGNARI
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  • For correspondence: carmela.fimognari@unibo.it
FAUSTO BERTI
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MICHAEL NÜSSE
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GIORGIO CANTELLI-FORTI
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PATRIZIA HRELIA
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Abstract

Background: Little is known regarding the potentially chemopreventive activity of cyanidin-3-O-β-glucopyranoside (Cy-g), the main anthocyanin present in the juice of pigmented oranges, apart from its antioxidant activity. After excluding a potential genotoxicity of Cy-g, its ability to induce apoptosis on transformed and normal T cells was analysed. In order to delineate the events leading to apoptosis, the expression of different proteins, known to be involved in apoptosis, was also measured. Materials and Methods: The evaluation of genotoxicity was performed by the micronucleus test. Flow cytometry was used for the analysis of apoptotic cells and proteins involved in the modulation of apoptosis. Results: Cy-g was nongenotoxic. Moreover, it induced apoptosis in both cell systems, modulated by an increase of p53 and bax proteins. Conclusion: These interesting biological properties should encourage further studies into the chemopreventive potential of Cy-g. Nevertheless, its activity in normal T cells underlines the need for extensive toxicological investigation.

  • Chemoprevention
  • anthocyanins
  • genotoxicity
  • apoptosis
  • lymphocytes

Footnotes

  • Received January 25, 2005.
  • Accepted May 13, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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In Vitro Anticancer Activity of Cyanidin-3-O-β-Glucopyranoside: Effects on Transformed and Non-transformed T Lymphocytes
CARMELA FIMOGNARI, FAUSTO BERTI, MICHAEL NÜSSE, GIORGIO CANTELLI-FORTI, PATRIZIA HRELIA
Anticancer Research Jul 2005, 25 (4) 2837-2840;

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In Vitro Anticancer Activity of Cyanidin-3-O-β-Glucopyranoside: Effects on Transformed and Non-transformed T Lymphocytes
CARMELA FIMOGNARI, FAUSTO BERTI, MICHAEL NÜSSE, GIORGIO CANTELLI-FORTI, PATRIZIA HRELIA
Anticancer Research Jul 2005, 25 (4) 2837-2840;
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