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Research ArticleExperimental Studies

Simultaneous Precise Chemoradiation under Inhalation Anesthesia in an Experimental Mouse Tumor Model

MARKUS ADAM, JULIA HENKE, CARSTEN NIEDER, WOLF ERHARDT and MICHAEL MOLLS
Anticancer Research July 2005, 25 (4) 2815-2820;
MARKUS ADAM
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JULIA HENKE
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CARSTEN NIEDER
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WOLF ERHARDT
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MICHAEL MOLLS
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Abstract

Background: Performing radiobiological experiments under general anesthesia is, in many cases, superior to treatment in unanesthetized animals or with intraperitoneal (i.p.) anesthesia. This is especially true for experiments where highly fractionated treatment schedules are used. Materials and Methods: An anesthesia system was employed to overcome several of the limitations associated with the use of pentobarbital and other i.p.-administered anesthetics in experimental radiotherapy. Results: Several different experiments with a total of 152 mice were performed. The total of all anesthesia exposures amounted to approximately 1,520. The duration of anesthesia ranged from 3 to 5 min per session. No complications related to the anesthetic procedure were observed. Conclusion: The present anesthesia/irradiation setup is a simple, safe and perfectly reproducible system where even multiple fractionated treatments can be performed under anesthesia with excellent tolerance. Our system allows easy and fast handling and immobilization and thus reduces experimental times.

  • Radiation therapy
  • chemotherapy
  • anesthesia

Footnotes

  • Received January 21, 2005.
  • Accepted April 14, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Simultaneous Precise Chemoradiation under Inhalation Anesthesia in an Experimental Mouse Tumor Model
MARKUS ADAM, JULIA HENKE, CARSTEN NIEDER, WOLF ERHARDT, MICHAEL MOLLS
Anticancer Research Jul 2005, 25 (4) 2815-2820;

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Simultaneous Precise Chemoradiation under Inhalation Anesthesia in an Experimental Mouse Tumor Model
MARKUS ADAM, JULIA HENKE, CARSTEN NIEDER, WOLF ERHARDT, MICHAEL MOLLS
Anticancer Research Jul 2005, 25 (4) 2815-2820;
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