Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

Active Succinate Dehydrogenase (SDH) and Lack of SDHD Mutations in Sporadic Paragangliomas

SIMONE BRAUN, KATHRIN RIEMANN, SUSAN KUPKA, PETER LEISTENSCHNEIDER, KARL SOTLAR, HEIDE SCHMID and NIKOLAUS BLIN
Anticancer Research July 2005, 25 (4) 2809-2814;
SIMONE BRAUN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KATHRIN RIEMANN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SUSAN KUPKA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
PETER LEISTENSCHNEIDER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KARL SOTLAR
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HEIDE SCHMID
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NIKOLAUS BLIN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: blin@uni-tuebingen.de
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Paragangliomas are benign, slow-growing tumours of the head and neck region. The candidate gene for familial and some sporadic paragangliomas, SDHD (succinate dehydrogenase, subunit D), has been mapped to the PGL1 locus in 11q23.3. Materials and Methods: Normal and tumour DNA of 17 patients with sporadic paragangliomas were analysed by sequencing (SDHD, SDHB and SDHC genes), fluorescence in situ hybridisation (FISH). In addition, loss of heterozygosity (LOH) and succinate dehydrogenase (SDH) enzyme activity assays were performed. Results and Conclusion: Only two patients from our collective showed SDH gene mutations, one in SDHD and one in SDHB, respectively. Moreover, SDH activity detected in 5/8 patients confirmed the fact that SDH inactivation is not a major event in sporadic paragangliomas. LOH and FISH analysis demonstrated a frequent loss of regions within chromosome 11, indicating that additional genes in 11q may play a role in tumour genesis of sporadic paragangliomas.

  • Glomus tumours
  • SDHD-
  • SDHB-
  • SDHC-gene
  • succinate dehydrogenase (SDH) enzyme activity
  • loss of heterozygosity (LOH)

Footnotes

  • ↵* These authors contributed equally to the work.

  • Received November 9, 2004.
  • Accepted April 11, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Active Succinate Dehydrogenase (SDH) and Lack of SDHD Mutations in Sporadic Paragangliomas
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
5 + 8 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Active Succinate Dehydrogenase (SDH) and Lack of SDHD Mutations in Sporadic Paragangliomas
SIMONE BRAUN, KATHRIN RIEMANN, SUSAN KUPKA, PETER LEISTENSCHNEIDER, KARL SOTLAR, HEIDE SCHMID, NIKOLAUS BLIN
Anticancer Research Jul 2005, 25 (4) 2809-2814;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Active Succinate Dehydrogenase (SDH) and Lack of SDHD Mutations in Sporadic Paragangliomas
SIMONE BRAUN, KATHRIN RIEMANN, SUSAN KUPKA, PETER LEISTENSCHNEIDER, KARL SOTLAR, HEIDE SCHMID, NIKOLAUS BLIN
Anticancer Research Jul 2005, 25 (4) 2809-2814;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • 2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells
  • Cancer Morphogenesis: Role of Mitochondrial Failure
  • Google Scholar

More in this TOC Section

  • Resveratrol Derivatives Inhibit Pro-survival Akt Signaling Pathway in Lung Cancer
  • Development of a Benzoxazine-derived Inhibitor Targeting Epithelial-to-Mesenchymal Transition in Lung Cancer
  • ITGAV Regulation of LGALS3BP-JUNB Axis Facilitates the Cell-to-Cell Adhesion and Invasiveness of Hepatic Cancer Cells
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire