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Research ArticleExperimental Studies

Cytokeratin Expression Correlates with Aneuploidy in Cytological Specimens of Melanoma Metastases

MONIKA KORABIOWSKA, ILKA RUSCHENBURG, HARALD SCHULZ, ANJA STEINACKER, PAWEL BORTKIEWICZ, MICHAEL SEVENICH, ULRICH BRINCK, CARLOS CORDON-CARDO and GÖSTA FISCHER
Anticancer Research July 2005, 25 (4) 2789-2792;
MONIKA KORABIOWSKA
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ILKA RUSCHENBURG
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HARALD SCHULZ
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ANJA STEINACKER
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PAWEL BORTKIEWICZ
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MICHAEL SEVENICH
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ULRICH BRINCK
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CARLOS CORDON-CARDO
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GÖSTA FISCHER
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Abstract

It has been postulated that the high malignancy of melanomas could be connected with an increased cytokeratin (CK) expression. In order to define the relationship between CK expression and genetic instability of melanoma metastases, ploidy-related parameters were compared in cytological specimens of CK-positive and CK-negative melanoma metastases. CK expression was investigated immunohistochemically in 35 melanoma liver metastases and in 52 melanoma lymphatic metastases. Ploidy-related parameters were evaluated on Feulgen-stained specimens with a CAS200 image analyzer. Cytokeratin was detected in 14 out of 35 melanoma liver metastases and in 24 out of 52 melanoma lymphatic metastases investigated. Significant differences between CK-positive and CK-negative melanoma metastases were found for the percentage of diploid cells, percentage of tetraploid cells, percentage of aneuploid cells between 4c and 8c, as well as for 5c exceeding rate. Our results confirmed that CK is present in more advanced (unstable), clearly aneuploid forms of melanoma metastases.

  • Melanoma metastases
  • cytokeratins
  • CAS200
  • image cytophotometry

Footnotes

  • Received January 18, 2005.
  • Accepted May 12, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Cytokeratin Expression Correlates with Aneuploidy in Cytological Specimens of Melanoma Metastases
MONIKA KORABIOWSKA, ILKA RUSCHENBURG, HARALD SCHULZ, ANJA STEINACKER, PAWEL BORTKIEWICZ, MICHAEL SEVENICH, ULRICH BRINCK, CARLOS CORDON-CARDO, GÖSTA FISCHER
Anticancer Research Jul 2005, 25 (4) 2789-2792;

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Cytokeratin Expression Correlates with Aneuploidy in Cytological Specimens of Melanoma Metastases
MONIKA KORABIOWSKA, ILKA RUSCHENBURG, HARALD SCHULZ, ANJA STEINACKER, PAWEL BORTKIEWICZ, MICHAEL SEVENICH, ULRICH BRINCK, CARLOS CORDON-CARDO, GÖSTA FISCHER
Anticancer Research Jul 2005, 25 (4) 2789-2792;
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