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Research ArticleExperimental Studies

An Experimental Study on the Therapeutic Effect of Consecutive Low-dose Cisplatin with Caffeine in Sarcoma-bearing Mice

AKIRA TAKEDA, HIROYUKI TSUCHIYA, TAKAHIRO TAJINO and SHIN-ICHI KIKUCHI
Anticancer Research July 2005, 25 (4) 2777-2784;
AKIRA TAKEDA
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  • For correspondence: takeda@fmu.ac.jp
HIROYUKI TSUCHIYA
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TAKAHIRO TAJINO
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SHIN-ICHI KIKUCHI
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Abstract

The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine. Materials and Methods: Human fibrosarcoma cells (HT-1080) were transplanted in BALB/C-nu mice. According to the administration of CDDP and caffeine, 5 groups were defined: HD-CDDP, LD-CDDP, HD-CDDP +caffeine, LD-CDDP +caffeine and control group. The total dose of CDDP was 3.5 or 6 mg/kg. CDDP was injected i.p. bolus (HD-CDDP) or divided into 5 days (LD-CDDP). Caffeine was injected i.p. at a dose of 60 mg/kg twice a day for 4 days. Results: Significant inhibition of tumor growth and prolongation of survival time were recognized in the HD- and LD-CDDP groups with and without caffeine compared to the control group. The caffeine-assisted groups had no advantage compared to the CDDP alone groups. Conclusion: The effects of LD-CDDP were similar to the effect of HD-CDDP.

  • Fibrosarcoma
  • chemotherapy
  • cisplatin

Footnotes

  • Received August 20, 2004.
  • Revision received March 22, 2005.
  • Accepted March 28, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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An Experimental Study on the Therapeutic Effect of Consecutive Low-dose Cisplatin with Caffeine in Sarcoma-bearing Mice
AKIRA TAKEDA, HIROYUKI TSUCHIYA, TAKAHIRO TAJINO, SHIN-ICHI KIKUCHI
Anticancer Research Jul 2005, 25 (4) 2777-2784;

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An Experimental Study on the Therapeutic Effect of Consecutive Low-dose Cisplatin with Caffeine in Sarcoma-bearing Mice
AKIRA TAKEDA, HIROYUKI TSUCHIYA, TAKAHIRO TAJINO, SHIN-ICHI KIKUCHI
Anticancer Research Jul 2005, 25 (4) 2777-2784;
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