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Research ArticleExperimental Studies

p53 Intronic G13964C Variant in Colon Cancer and its Association with HPV

NUR BUYRU, AYDA TEZOL and NEJAT DALAY
Anticancer Research July 2005, 25 (4) 2767-2769;
NUR BUYRU
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AYDA TEZOL
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NEJAT DALAY
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  • For correspondence: ndalay@yahoo.com
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Abstract

Background: Inactivation of p53 is the most common change identified in human cancer. Nucleotide alterations in p53 intron 6 have been reported to be associated with the dysregulation of p53 function and tumor development. The aim of our study was to assess whether the intron 6 G13964C variant of the p53 gene is associated with the presence of human papillomavirus (HPV) as a risk factor in colon cancer. Materials and Methods: To determine whether the intronic G13964C alteration is involved in colon carcinogenesis, surgical specimens from 55 patients with colon cancer and HPV-positive tumors were examined by PCR-RFLP. Blood samples from 77 healthy subjects were used as the control group. Results: The 13964C variant was found in 14.5% of colon cancer patients and 12.9% of the control subjects. One patient and two controls were homozygous for this base change. Conclusion: No evidence of a significant association between the p53 G13964C allele and colon carcinoma was found.

  • p53
  • intron 6
  • colon cancer

Footnotes

  • Received February 1, 2005.
  • Accepted May 2, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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p53 Intronic G13964C Variant in Colon Cancer and its Association with HPV
NUR BUYRU, AYDA TEZOL, NEJAT DALAY
Anticancer Research Jul 2005, 25 (4) 2767-2769;

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p53 Intronic G13964C Variant in Colon Cancer and its Association with HPV
NUR BUYRU, AYDA TEZOL, NEJAT DALAY
Anticancer Research Jul 2005, 25 (4) 2767-2769;
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