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Research ArticleExperimental Studies

Serum Levels of Interleukin-6 in Patients with Primary Head and Neck Squamous Cell Carcinoma

FRANK RIEDEL, INKA ZAISS, DENISE HERZOG, KARL GÖTTE, RAMIN NAIM and KARL HÖRMANN
Anticancer Research July 2005, 25 (4) 2761-2765;
FRANK RIEDEL
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  • For correspondence: frank.riedel@hno.ma.uni-heidelberg.de
INKA ZAISS
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DENISE HERZOG
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KARL GÖTTE
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RAMIN NAIM
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KARL HÖRMANN
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Abstract

Interleukin (IL)-6 plays a central role as a differentiation and growth factor of tumor cells. IL-6 has been identified in a wide variety of malignancies, including head and neck squamous cell carcinomas (HNSCC). The aim of this study was to investigate the association between the serum levels of IL-6 in HNSCC patients and the biological characteristics of the tumor as well as the clinicopathological status of the patients. The circulating level of IL-6 in sera from patients with various HNSCC (n=90) as well as from healthy normal controls (n=39) was investigated. Serum IL-6 concentrations were determined as serum immunoreactivity using a quantitative sandwich enzyme immunoassay technique. For statistical analysis, the Kruskal-Wallis test was performed. The majority of the patients with HNSCC were found to have high serum IL-6 concentrations. The IL-6 levels in the sera of patients with cancer ranged from below the detection limit to 312.8 pg/ml (mean, 19.5 pg/ml). In contrast, the IL-6 serum levels in 39 healthy individuals ranged from below the detection limit to 52.2 pg/ml (mean, 6.0 pg/ml), with the concentration being significantly higher in HNSCC patients (p<0.001). Furthermore, the correlation of the IL-6 serum concentration with tumor stage was significant (p=0.04). Accordingly, there was a significant difference of IL-6 serum concentration of tumors with positive and negative lymph nodes (p=0.045), with concentration being significantly higher in lymph node-positive tumors. Our data on elevated IL-6 serum levels in the majority of HNSCC cancer patients and its correlation with tumor stage and lymph node status suggest that serum IL-6 reflects the proliferative activity of the tumor in patients with head and neck cancer. IL-6 serum determinations might serve as a biological marker and help to identify advanced head and neck tumors.

  • Interleukin-6
  • serum level
  • head and neck squamous cell carcinoma

Footnotes

  • Received February 1, 2005.
  • Accepted May 3, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Serum Levels of Interleukin-6 in Patients with Primary Head and Neck Squamous Cell Carcinoma
FRANK RIEDEL, INKA ZAISS, DENISE HERZOG, KARL GÖTTE, RAMIN NAIM, KARL HÖRMANN
Anticancer Research Jul 2005, 25 (4) 2761-2765;

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Serum Levels of Interleukin-6 in Patients with Primary Head and Neck Squamous Cell Carcinoma
FRANK RIEDEL, INKA ZAISS, DENISE HERZOG, KARL GÖTTE, RAMIN NAIM, KARL HÖRMANN
Anticancer Research Jul 2005, 25 (4) 2761-2765;
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