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Research ArticleExperimental Studies

Recombinant Interleukin-2 Enhanced the Antitumor Effect of ADV/RSV-HSV-tk/ACV Therapy in a Murine Bladder Cancer Model

SHUJI TERAO, TOSHIRO SHIRAKAWA, KAZUMASA GODA, SADAO KAMIDONO, MASATO FUJISAWA and AKINOBU GOTOH
Anticancer Research July 2005, 25 (4) 2757-2760;
SHUJI TERAO
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TOSHIRO SHIRAKAWA
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KAZUMASA GODA
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SADAO KAMIDONO
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MASATO FUJISAWA
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AKINOBU GOTOH
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  • For correspondence: terao@med.kobe-u.ac.jp
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Abstract

Background: Previous studies demonstrated the antitumor effects of IL-2 and ADV/RSV-HSV-tk in bladder tumor models. In our study, we employed the intramuscular injection of recombinant IL-2 combined with ADV/RSV-HSV-tk gene therapy in the MBT-2 murine bladder tumor model. Materials and Methods: In the in vitro study, after adenoviral gene transduction efficiency had been assessed, the cytotoxicity of ADV/RSV-HSV-tk/ACV was examined. In the in vivo study, ADV/RSV-HSV-tk was injected into MBT-2 subcutaneous tumors, ACV was injected intraperitoneally daily for 13 days and recombinant IL-2 was injected intramuscularly daily for 10 days. Results: The X-gal staining of MBT-2 cells infected with 125 multiplicity of injection (MOI) indicated >20% adenoviral gene transduction efficiency. The cell growth of MBT-2 infected with 125 MOI was significantly inhibited by 40 μM of ACV. In the in vivo study, the combination therapy significantly inhibited tumor growth in the MBT-2 tumor model. Conclusion: The systemic administration of recombinant IL-2 in combination with HSV-tk gene therapy exhibited an enhanced antitumor effect.

  • Gene therapy
  • bladder cancer
  • adenovirus
  • recombinant IL-2

Footnotes

  • Received March 30, 2005.
  • Accepted May 26, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Recombinant Interleukin-2 Enhanced the Antitumor Effect of ADV/RSV-HSV-tk/ACV Therapy in a Murine Bladder Cancer Model
SHUJI TERAO, TOSHIRO SHIRAKAWA, KAZUMASA GODA, SADAO KAMIDONO, MASATO FUJISAWA, AKINOBU GOTOH
Anticancer Research Jul 2005, 25 (4) 2757-2760;

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Recombinant Interleukin-2 Enhanced the Antitumor Effect of ADV/RSV-HSV-tk/ACV Therapy in a Murine Bladder Cancer Model
SHUJI TERAO, TOSHIRO SHIRAKAWA, KAZUMASA GODA, SADAO KAMIDONO, MASATO FUJISAWA, AKINOBU GOTOH
Anticancer Research Jul 2005, 25 (4) 2757-2760;
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