Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

Predictors of Response to Chemo-radiotherapy and Radiotherapy for Esophageal Squamous Cell Carcinoma

TATSUYA MIYAZAKI, HIROYUKI KATO, AHMAD FARIED, MAKOTO SOHDA, MASANOBU NAKAJIMA, YASUYUKI FUKAI, NORIHIRO MASUDA, RYOKUHEI MANDA, MINORU FUKUCHI, HITOSHI OJIMA, KATSUHIKO TSUKADA and HIROYUKI KUWANO
Anticancer Research July 2005, 25 (4) 2749-2755;
TATSUYA MIYAZAKI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: tatsuyam@showa.gunma-u.ac.jp
HIROYUKI KATO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AHMAD FARIED
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MAKOTO SOHDA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MASANOBU NAKAJIMA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YASUYUKI FUKAI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NORIHIRO MASUDA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
RYOKUHEI MANDA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MINORU FUKUCHI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HITOSHI OJIMA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KATSUHIKO TSUKADA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HIROYUKI KUWANO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: The sensitivity of tumors to chemotherapy and radiotherapy differs from one case to another and may be influenced by the expression of biological molecules. The presence of six potential predictive markers in esophageal squamous cell carcinoma (ESCC) was investigated and the data obtained were related to the response of the tumors to chemo-radiotherapy and radiotherapy. Materials and Methods: Biopsy specimens were obtained from 61 patients with ESCC before treatment with chemo-radiotherapy (31 patients) or radiotherapy (30 patients). External radiotherapy was delivered by a two-field technique to a total of 60-70 Gray. Concurrent chemotherapy consisted of cisplatin or nedaplatin and 5-fluorouracil administered intravenously. The patients were examined before and after treatment by endoscopy, esophagography and computed tomography. The clinical response was classified as effective (>50% decrease in primary lesion), or ineffective. Immunohistochemical staining for p53, p21, bax, bcl2, heat-shock protein (Hsp) 27 and Hsp70 was performed on the biopsy specimens before therapy. Results: The primary tumor response was effective in 73.8% (45/61) and ineffective in 26.2% (16/61) of patients. Tumors with p53-positive expression were less sensitive than p53-negative tumors (p=0.033). p21-positive patients (p=0.027), and Hsp27-negative (p=0.0057) and Hsp70-negative patients (p=0.010) were all good responders. Neither bcl2 nor bax expression was related to the efficacy of therapy. Multivariate analysis revealed that Hsp27 was the most reliable predictor of the effect of chemo-radiotherapy and radiotherapy among the four potential markers. p53-negative and Hsp70-negative patients had a more favorable prognosis than p53- and Hsp70-positive patients (p=0.039, p=0.038, respectively). Conclusion: Expression of Hsp27 was a good predictor of the response of ESCC to chemo-radiotherapy and radiotherapy.

  • Esophageal squamous cell carcinoma
  • chemo-radiotherapy
  • Hsp27
  • Hsp70
  • p21
  • p53
  • bax
  • bcl2

Footnotes

  • Received January 11, 2005.
  • Accepted May 5, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Predictors of Response to Chemo-radiotherapy and Radiotherapy for Esophageal Squamous Cell Carcinoma
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
18 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Predictors of Response to Chemo-radiotherapy and Radiotherapy for Esophageal Squamous Cell Carcinoma
TATSUYA MIYAZAKI, HIROYUKI KATO, AHMAD FARIED, MAKOTO SOHDA, MASANOBU NAKAJIMA, YASUYUKI FUKAI, NORIHIRO MASUDA, RYOKUHEI MANDA, MINORU FUKUCHI, HITOSHI OJIMA, KATSUHIKO TSUKADA, HIROYUKI KUWANO
Anticancer Research Jul 2005, 25 (4) 2749-2755;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Predictors of Response to Chemo-radiotherapy and Radiotherapy for Esophageal Squamous Cell Carcinoma
TATSUYA MIYAZAKI, HIROYUKI KATO, AHMAD FARIED, MAKOTO SOHDA, MASANOBU NAKAJIMA, YASUYUKI FUKAI, NORIHIRO MASUDA, RYOKUHEI MANDA, MINORU FUKUCHI, HITOSHI OJIMA, KATSUHIKO TSUKADA, HIROYUKI KUWANO
Anticancer Research Jul 2005, 25 (4) 2749-2755;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Anti-tumor Effect of Activated Canine B Cells With Interleukin-21 and Anti-B Cell Receptor
  • Claudin-10 in the Blood Brain Barrier Function of Cerebral Endothelial Cells and Transendothelial Invasion of Breast Cancer Cells
  • Development of Genetically Engineered Feeder Cells for Natural Killer Cell Expansion
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2023 Anticancer Research

Powered by HighWire