Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

Effects of Calcitriol, Seocalcitol, and Medium-chain Triglyceride on a Canine Transitional Cell Carcinoma Cell Line

THATTAWAN KAEWSAKHORN, WILLIAM C. KISSEBERTH, CHARLES C. CAPEN, KATHLEEN A. HAYES, MARTIN J. CALVERLEY and NONGNUCH INPANBUTR
Anticancer Research July 2005, 25 (4) 2689-2696;
THATTAWAN KAEWSAKHORN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
WILLIAM C. KISSEBERTH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CHARLES C. CAPEN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KATHLEEN A. HAYES
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MARTIN J. CALVERLEY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NONGNUCH INPANBUTR
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: inpanbutr.1@osu.edu
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background: Transitional cell carcinoma (TCC) in dogs is associated with high morbidity and mortality. Calcitriol and its analog seocalcitol, combined with medium-chain triglyceride (MCT), have potential for the treatment of this disease. Materials and Methods: TCC cells were treated with calcitriol or seocalcitol, alone or combined with MCT. Cell growth, cell cycle kinetics, vitamin D receptor (VDR) localization and expression, and Bcl-2 expression were measured. Results: Canine TCC expresses high levels of nuclear VDR. Furthermore, calcitriol and seocalcitol significantly inhibited cell growth and calcitriol caused G0/G1 cell cycle arrest. Bcl-2 expression was slightly decreased in cells treated with these compounds, although no significant changes in VDR expression were observed. MCT enhanced the growth inhibitory effect of both compounds. Conclusion: Calcitriol and seocalcitol inhibited TCC cell growth via induction of cell cycle arrest and MCT enhanced this effect. Therefore, calcitriol and seocalcitol with MCT may have therapeutic potential for canine bladder cancer.

  • Vitamin D
  • calcitriol
  • vitamin D analog
  • seocalcitol
  • medium-chain triglyceride
  • canine transitional cell carcinoma
  • growth inhibition
  • cell cycle
  • VDR

Footnotes

  • Abbreviations: Calcitriol, 1α, 25-dihydroxyvitamin D3; Seocalcitol, 22, 24-diene-24a,26a,27a-trihomo-1α, 25-dihydroxyvitamin D3; MCT, medium-chain triglyceride; TCC cell line, canine transitional cell carcinoma cell line.

  • Received May 9, 2005.
  • Accepted May 18, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effects of Calcitriol, Seocalcitol, and Medium-chain Triglyceride on a Canine Transitional Cell Carcinoma Cell Line
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
2 + 2 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Effects of Calcitriol, Seocalcitol, and Medium-chain Triglyceride on a Canine Transitional Cell Carcinoma Cell Line
THATTAWAN KAEWSAKHORN, WILLIAM C. KISSEBERTH, CHARLES C. CAPEN, KATHLEEN A. HAYES, MARTIN J. CALVERLEY, NONGNUCH INPANBUTR
Anticancer Research Jul 2005, 25 (4) 2689-2696;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Effects of Calcitriol, Seocalcitol, and Medium-chain Triglyceride on a Canine Transitional Cell Carcinoma Cell Line
THATTAWAN KAEWSAKHORN, WILLIAM C. KISSEBERTH, CHARLES C. CAPEN, KATHLEEN A. HAYES, MARTIN J. CALVERLEY, NONGNUCH INPANBUTR
Anticancer Research Jul 2005, 25 (4) 2689-2696;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells
  • Google Scholar

More in this TOC Section

  • Anti-tumor Effect of Activated Canine B Cells With Interleukin-21 and Anti-B Cell Receptor
  • Claudin-10 in the Blood Brain Barrier Function of Cerebral Endothelial Cells and Transendothelial Invasion of Breast Cancer Cells
  • Development of Genetically Engineered Feeder Cells for Natural Killer Cell Expansion
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2023 Anticancer Research

Powered by HighWire