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Research ArticleExperimental Studies

Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, Without Altering its Antitumor Properties

ORLANDO GHIRARDI, PIETRO LO GIUDICE, CLAUDIO PISANO, MARIO VERTECHY, AUGUSTA BELLUCCI, LOREDANA VESCI, SANTE CUNDARI, MARIAROSARIA MILOSO, LAURA MARIA RIGAMONTI, GABRIELLA NICOLINI, CLAUDIO ZANNA and PAOLO CARMINATI
Anticancer Research July 2005, 25 (4) 2681-2687;
ORLANDO GHIRARDI
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  • For correspondence: orlando.ghirardi@sigma-tau.it
PIETRO LO GIUDICE
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CLAUDIO PISANO
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MARIO VERTECHY
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AUGUSTA BELLUCCI
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LOREDANA VESCI
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SANTE CUNDARI
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MARIAROSARIA MILOSO
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LAURA MARIA RIGAMONTI
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GABRIELLA NICOLINI
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CLAUDIO ZANNA
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PAOLO CARMINATI
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Abstract

Background: Oxaliplatin (OHP) is severely neurotoxic and induces the onset of a disabling sensory peripheral neuropathy. Acetyl-L-carnitine (ALC), a natural compound with neuroprotective action, was tested to determine whether it plays a protective role in OHP-induced neuropathy. Materials and Methods: Peripheral neuropathy was induced in Wistar rats, and the effect of OHP alone or in combination with ALC was assessed, using behavioral and neurophysiological methods. Moreover, ALC interference on OHP antitumor activity was investigated using several in vitro and in vivo models. Results: ALC-co-treatment reduced the neurotoxicity of OHP when it was coadministered. Furthermore, the administration of OHP, once OHP-induced neuropathy was established, significantly mitigated its severity. Finally, experiments in different tumor systems indicated that ALC does not interfere with the antitumor effects of OHP. Conclusion: ALC is effective in the prevention and treatment of chronic OHP-induced peripheral neurotoxicity in an experimental rat model.

  • Acetyl-L-carnitine
  • oxaliplatin
  • neurotoxicity

Footnotes

  • Received December 3, 2004.
  • Accepted April 13, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, Without Altering its Antitumor Properties
ORLANDO GHIRARDI, PIETRO LO GIUDICE, CLAUDIO PISANO, MARIO VERTECHY, AUGUSTA BELLUCCI, LOREDANA VESCI, SANTE CUNDARI, MARIAROSARIA MILOSO, LAURA MARIA RIGAMONTI, GABRIELLA NICOLINI, CLAUDIO ZANNA, PAOLO CARMINATI
Anticancer Research Jul 2005, 25 (4) 2681-2687;

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Acetyl-L-Carnitine Prevents and Reverts Experimental Chronic Neurotoxicity Induced by Oxaliplatin, Without Altering its Antitumor Properties
ORLANDO GHIRARDI, PIETRO LO GIUDICE, CLAUDIO PISANO, MARIO VERTECHY, AUGUSTA BELLUCCI, LOREDANA VESCI, SANTE CUNDARI, MARIAROSARIA MILOSO, LAURA MARIA RIGAMONTI, GABRIELLA NICOLINI, CLAUDIO ZANNA, PAOLO CARMINATI
Anticancer Research Jul 2005, 25 (4) 2681-2687;
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