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Research ArticleExperimental Studies

Cyclooxygenase-2 Expression in Human Soft-tissue Sarcomas is Related to Epithelial Differentation

PATRIK LASSUS, ARI RISTIMÄKI, RIIKKA HUUHTANEN, ERKKI TUKIAINEN, SIRPA ASKO-SELJAVAARA, LEIF C. ANDERSSON, MARKKU MIETTINEN, CARL BLOMQVIST, CAJ HAGLUND and TOM BÖHLING
Anticancer Research July 2005, 25 (4) 2669-2674;
PATRIK LASSUS
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  • For correspondence: patrik.lassus@hus.fi
ARI RISTIMÄKI
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RIIKKA HUUHTANEN
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ERKKI TUKIAINEN
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SIRPA ASKO-SELJAVAARA
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LEIF C. ANDERSSON
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MARKKU MIETTINEN
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CARL BLOMQVIST
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CAJ HAGLUND
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TOM BÖHLING
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Abstract

Background: Cyclooxygenase-2 (Cox-2) is expressed by several types of epithelial malignancies, i.e., carcinomas, and inhibition of Cox-2 may have a therapeutic role in chemoprevention and treatment of cancer. The role of Cox-2 in non-epithelial malignancies, however, is unclear. Materials and Methods: We investigated, by immuno- histochemistry, the expression of Cox-2 in 103 human soft-tissue sarcomas. Results: All 10 biphasic synovial sarcomas were positive for Cox-2, but positivity was observable only in the epithelial component of these tumours. Excluding sarcomas with epithelial differentation, uniform staining of the tumour was observed in only 2 samples. In addition, positivity for Cox-2 appeared in tumour cells in only 18 samples around necrotic areas. Conclusion: In human soft-tissue sarcomas, Cox-2 expression seems to be associated with epithelial differentation and, in some types of sarcomas, to be expressed in otherwise negative tumours at sites of necrosis.

  • Cox-2
  • STS
  • immunohistochemistry
  • soft tissue sarcomas
  • epithelial differentiation

Footnotes

  • Received February 16, 2005.
  • Accepted May 6, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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Cyclooxygenase-2 Expression in Human Soft-tissue Sarcomas is Related to Epithelial Differentation
PATRIK LASSUS, ARI RISTIMÄKI, RIIKKA HUUHTANEN, ERKKI TUKIAINEN, SIRPA ASKO-SELJAVAARA, LEIF C. ANDERSSON, MARKKU MIETTINEN, CARL BLOMQVIST, CAJ HAGLUND, TOM BÖHLING
Anticancer Research Jul 2005, 25 (4) 2669-2674;

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Cyclooxygenase-2 Expression in Human Soft-tissue Sarcomas is Related to Epithelial Differentation
PATRIK LASSUS, ARI RISTIMÄKI, RIIKKA HUUHTANEN, ERKKI TUKIAINEN, SIRPA ASKO-SELJAVAARA, LEIF C. ANDERSSON, MARKKU MIETTINEN, CARL BLOMQVIST, CAJ HAGLUND, TOM BÖHLING
Anticancer Research Jul 2005, 25 (4) 2669-2674;
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