Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleExperimental Studies

RUNX3 Promoter Region is Specifically Methylated in Poorly-differentiated Colorectal Cancer

YASUHIRO IMAMURA, KENJI HIBI, MASAHIKO KOIKE, MICHITAKA FUJIWARA, YASUHIRO KODERA, KATSUKI ITO and AKIMASA NAKAO
Anticancer Research July 2005, 25 (4) 2627-2630;
YASUHIRO IMAMURA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KENJI HIBI
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: khibi@med.nagoya-u.ac.jp
MASAHIKO KOIKE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MICHITAKA FUJIWARA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
YASUHIRO KODERA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KATSUKI ITO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AKIMASA NAKAO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Background, Materials and Methods: It has recently become clear that RUNX3 expression is frequently silenced by aberrant methylation in gastric cancers. In this study, we investigated the methylation status of the RUNX3 gene in 92 resected primary colorectal cancers using methylation-specific PCR (MSP) and correlated the results with the clinicopathological features of affected patients. Results: Aberrant promoter methylation of the RUNX3 gene was detected in 31 out of 92 (34%) colorectal cancers. A significant difference in histology (p=0.028) was also found on comparing the RUNX3 methylation of poorly-differentiated colorectal cancers to that of other differentiated ones. Conclusion: RUNX3 aberrant methylation might play an important role in colorectal cancers, especially in poorly-differentiated colorectal cancers.

  • RUNX3
  • colorectal cancer
  • methylation-specific PCR

Footnotes

  • ↵* These authors equally contributed to this work.

  • Abbreviations: Methylation-specific PCR, MSP.

  • Received February 23, 2005.
  • Accepted April 21, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
RUNX3 Promoter Region is Specifically Methylated in Poorly-differentiated Colorectal Cancer
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 3 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
RUNX3 Promoter Region is Specifically Methylated in Poorly-differentiated Colorectal Cancer
YASUHIRO IMAMURA, KENJI HIBI, MASAHIKO KOIKE, MICHITAKA FUJIWARA, YASUHIRO KODERA, KATSUKI ITO, AKIMASA NAKAO
Anticancer Research Jul 2005, 25 (4) 2627-2630;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
RUNX3 Promoter Region is Specifically Methylated in Poorly-differentiated Colorectal Cancer
YASUHIRO IMAMURA, KENJI HIBI, MASAHIKO KOIKE, MICHITAKA FUJIWARA, YASUHIRO KODERA, KATSUKI ITO, AKIMASA NAKAO
Anticancer Research Jul 2005, 25 (4) 2627-2630;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Demethylation of RUNX3 by Vincristine in Colorectal Adenocarcinoma Cells
  • Google Scholar

More in this TOC Section

  • Anti-tumor Effect of Activated Canine B Cells With Interleukin-21 and Anti-B Cell Receptor
  • Claudin-10 in the Blood Brain Barrier Function of Cerebral Endothelial Cells and Transendothelial Invasion of Breast Cancer Cells
  • Development of Genetically Engineered Feeder Cells for Natural Killer Cell Expansion
Show more Experimental Studies

Similar Articles

Anticancer Research

© 2023 Anticancer Research

Powered by HighWire