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Review ArticleExperimental Studies

The Elastin Connection and Melanoma Progression

WILLIAM HORNEBECK, ARNAUD ROBINET, LAURENT DUCA, FRANK ANTONICELLI, JEAN WALLACH and GEORGES BELLON
Anticancer Research July 2005, 25 (4) 2617-2625;
WILLIAM HORNEBECK
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  • For correspondence: william.hornebeck@univ-reims.fr
ARNAUD ROBINET
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LAURENT DUCA
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FRANK ANTONICELLI
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JEAN WALLACH
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GEORGES BELLON
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Abstract

Matrikines, i.e. matrix fragments with cytokine-like properties, have been ascribed a major role in regulating tumour progression. The invasive front of melanoma is characterised by intense fragmentation of dermal elastic fibres. Elastase-mediated elastolysis liberates elastin fragments, i.e. elastokines, that stimulate several aspects of melanoma progression such as to enhance melanoma cell invasion through type I collagen or increase angiogenesis. Induced-membrane-type1 metalloprotease (MT1-MMP) expression following elastin receptor (S-Gal) occupancy by elastokines is responsible for those biological activities. Several matrix-derived peptides with a GXXPG consensus sequence adopting a type VIII β-turn conformation were as potent as elastokines in promoting angiogenesis in a Matrigel assay, and galectin-3 also contains several similar repeats within its N-terminal domain. We propose that S-Gal might constitute a novel therapeutic target for controlling melanoma progression.

  • Elastin
  • melanoma
  • matrikines
  • galectin-3
  • review

Footnotes

  • Received March 28, 2005.
  • Accepted May 13, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (4)
Anticancer Research
Vol. 25, Issue 4
1 Jul 2005
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The Elastin Connection and Melanoma Progression
WILLIAM HORNEBECK, ARNAUD ROBINET, LAURENT DUCA, FRANK ANTONICELLI, JEAN WALLACH, GEORGES BELLON
Anticancer Research Jul 2005, 25 (4) 2617-2625;

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The Elastin Connection and Melanoma Progression
WILLIAM HORNEBECK, ARNAUD ROBINET, LAURENT DUCA, FRANK ANTONICELLI, JEAN WALLACH, GEORGES BELLON
Anticancer Research Jul 2005, 25 (4) 2617-2625;
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