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Research ArticleExperimental Studies

Effects of Alpha-hederin and Thymoquinone, constituents of Nigella sativa, on Human Cancer Cell Lines

SARA ROONEY and M.F. RYAN
Anticancer Research May 2005, 25 (3B) 2199-2204;
SARA ROONEY
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M.F. RYAN
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  • For correspondence: MFRyan@ucd.ie
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Abstract

The separate effects of alpha-hederin and thymoquinone, the two principal bioactive constituents of Nigella sativa, on four human cancer cell lines [A549 (lung carcinoma), HEp-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) and MIA PaCa-2 (pancreas carcinoma)] were investigated. Alpha-hederin was also examined as a pro-drug. Each assessment quantified both cytotoxic and apoptotic/necrotic effects. Alpha-hederin and thymoquinone separately induced a dose- and time-dependent effect on the cell lines tested. HEp-2 cells were the most sensitive, exhibiting apoptosis with a higher incidence following thymoquinone treatment. Pre-treatment of cells with alpha-hederin, followed by thymoquinone or cisplatin, did not enhance the cytotoxicity or apoptosis induced by either drug. So, the membrane-perforating properties associated with saponins, here represented by alpha-hederin, enhance neither cytotoxicity nor apoptosis of these cancer cells.

  • Nigella sativa
  • alpha-hederin
  • thymoquinone

Footnotes

  • Received March 21, 2005.
  • Accepted April 4, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (3B)
Anticancer Research
Vol. 25, Issue 3B
1 May 2005
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Effects of Alpha-hederin and Thymoquinone, constituents of Nigella sativa, on Human Cancer Cell Lines
SARA ROONEY, M.F. RYAN
Anticancer Research May 2005, 25 (3B) 2199-2204;

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Effects of Alpha-hederin and Thymoquinone, constituents of Nigella sativa, on Human Cancer Cell Lines
SARA ROONEY, M.F. RYAN
Anticancer Research May 2005, 25 (3B) 2199-2204;
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