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Research ArticleClinical Studies

Neutron Therapy, Prognostic Factors and Dedifferentiation of Adenoid Cystic Carcinomas (ACC) of Salivary Glands

SOPHIE BRACKROCK, ANDREAS KRÜLL, KERSTIN RÖSER, RUDOLF SCHWARZ, LUTZ RIETHDORF and WINFRIED ALBERTI
Anticancer Research March 2005, 25 (2B) 1321-1326;
SOPHIE BRACKROCK
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  • For correspondence: sophie@brackrock.de
ANDREAS KRÜLL
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KERSTIN RÖSER
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RUDOLF SCHWARZ
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LUTZ RIETHDORF
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WINFRIED ALBERTI
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Abstract

Purpose: Analysis of the efficacy of fast neutron radiotherapy in the treatment of adenoid cystic carcinomas (ACC) of the salivary glands, identification of prognostic variables and dedifferentiation after radiotherapy. Patients and Methods: Histological slides of primary and recurrent lesions of 71 patients were reviewed to confirm the diagnosis and to analyse subtypes. Median follow-up was 52 months. Local control rate and overall survival were analysed in multivariate analysis. Complications are also described. Results: Primary vs. recurrent therapy (p=0.001), margin-status (p=0.01) and subtype (p=0.019) influenced overall survival. Primary vs. recurrent therapy (p=0.001), margin-status (p=0.018) and T-stage (p=0.043) influenced local control rate. Dedifferentiation was seen in only 1/17 cases. Conclusion: The calculated prognostic factors illustrate the importance of a radical primary therapy. Histological subtype is a significant additional factor for overall survival and, in case of dedifferentiation, it is a strong predictor of a detrimental outcome.

  • Neutron therapy
  • adenoid cystic carcinoma
  • dedifferentiation
  • histological subtype
  • salivary glands
  • head and neck

Footnotes

  • Received June 15, 2004.
  • Revision received January 3, 2005.
  • Accepted February 8, 2005.
  • Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 25 (2B)
Anticancer Research
Vol. 25, Issue 2B
1 Mar 2005
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Neutron Therapy, Prognostic Factors and Dedifferentiation of Adenoid Cystic Carcinomas (ACC) of Salivary Glands
SOPHIE BRACKROCK, ANDREAS KRÜLL, KERSTIN RÖSER, RUDOLF SCHWARZ, LUTZ RIETHDORF, WINFRIED ALBERTI
Anticancer Research Mar 2005, 25 (2B) 1321-1326;

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Neutron Therapy, Prognostic Factors and Dedifferentiation of Adenoid Cystic Carcinomas (ACC) of Salivary Glands
SOPHIE BRACKROCK, ANDREAS KRÜLL, KERSTIN RÖSER, RUDOLF SCHWARZ, LUTZ RIETHDORF, WINFRIED ALBERTI
Anticancer Research Mar 2005, 25 (2B) 1321-1326;
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