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Research ArticleExperimental Studies

Re-distribution of Tenascin-C in the Parotid Acinar Cells. An Early Marker of Radiation-induced Damage of Salivary Glands?

S. G. HAKIM, I. LAUER, R. NADROWITZ, A. BERNDT, H. KOSMEHL and P. SIEG
Anticancer Research September 2004, 24 (5A) 2841-2846;
S. G. HAKIM
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I. LAUER
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R. NADROWITZ
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A. BERNDT
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H. KOSMEHL
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P. SIEG
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Abstract

Purpose: In order to investigate the early changes in the expression of tenascin-C, following irradiation and the associated functional impairment of salivary glands. Materials and Methods: Fifteen rabbits were used for the study. Five provided control parotid gland tissue and a further 10 rabbits were scintigraphically examined prior to and 24 h after 15/30 Gy. Glands were studied histologically using HE-staining and tenascin-C antibodies. Results: Reduction in the salivary ejection fraction (SEF) was observed in all irradiated glands. Simultaneously, a marked re-distribution of tenascin-C expression was noticed. Reactivity detected in the intercalated, secretory ducts and perineurinal regions prior to radiation was noticed intracellularly after 24 h. Furthermore, nerves showed tenascin-C expression in the Schwann cells, but no longer perineurinally. Myofibroblasts were also observed in the stroma. Conclusion: This study proves the ability to predict functional disorders of salivary function as early as 24 h after radiation and provides evidence of the participation of tenascin-C in the pathological process of radiation-induced damage in salivary glands.

Footnotes

    • Received March 19, 2004.
    • Accepted August 17, 2004.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (5A)
Anticancer Research
Vol. 24, Issue 5A
September-October 2004
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Re-distribution of Tenascin-C in the Parotid Acinar Cells. An Early Marker of Radiation-induced Damage of Salivary Glands?
S. G. HAKIM, I. LAUER, R. NADROWITZ, A. BERNDT, H. KOSMEHL, P. SIEG
Anticancer Research Sep 2004, 24 (5A) 2841-2846;

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Re-distribution of Tenascin-C in the Parotid Acinar Cells. An Early Marker of Radiation-induced Damage of Salivary Glands?
S. G. HAKIM, I. LAUER, R. NADROWITZ, A. BERNDT, H. KOSMEHL, P. SIEG
Anticancer Research Sep 2004, 24 (5A) 2841-2846;
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