Validation of the Limited-sampling Models for Carboplatin AUC in Combination Chemotherapy with Taxanes

Abstract

We previously developed limited-sampling models (LSM) for estimation of the area under the concentration curve (AUC) of free carboplatin (Anticancer Res 17: 4571-4576, 1997). The one-point model was: AUC (mg/ml × min)=0.93 × C_3h + 0.47 and the two-point model was: AUC (mg/ml × min)=0.16 × C_1h + 2.26 × C_8h + 0.75, in which C_3h, C_1h and C_8h represented the plasma concentration, sampled at 3 h, 1 h and 8 h after the start of a 1-h carboplatin infusion, respectively. In this study, we tried to confirm the utility of our LSMs in combination chemotherapy with taxanes. We obtained 29 data series from 29 patients who received carboplatin in combination with docetaxel (n=16) or paclitaxel (n=13). The actual AUC was strongly correlated with the AUC calculated from both one- and two-point models (one-point model; the mean prediction error (MPE)=-4.44±2.15%, the root mean squared error (RMSE)=12.22±0.84%, two-point model; MPE=-1.89±1.66%, RMSE=8.99±0.81%). Our LSMs proved to be unbiased and precise and are also useful for calculating carboplatin AUC in combination with taxanes.