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Research ArticleExperimental Studies

Expression of Interleukin-21 and -23 in Human Esophageal Tumors Produced Antitumor Effects in Nude Mice

BAOEN SHAN, LING YU, OSAMU SHIMOZATO, QIAOXIA LI and MASATOSHI TAGAWA
Anticancer Research January 2004, 24 (1) 79-82;
BAOEN SHAN
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LING YU
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OSAMU SHIMOZATO
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QIAOXIA LI
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MASATOSHI TAGAWA
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Abstract

Interleukin (IL)-21 induces proliferation of activated T and natural killer (NK) cells and enhances the lytic function of NK cells. IL-23, a heterodimer composed of p19 and p40 molecule, can also enhance T cell proliferation and interferon-Á production from activated T cells; however, its effects on NK cells are currently unknown. We therefore examined whether human tumors expressing IL-21 or IL-23 could produce antitumor effects in inoculated nude mice. Esophageal tumor T.Tn cells were retrovirally transduced with the IL-21 gene (T.Tn/IL-21) or the p19-linked p40 genes (T.Tn/IL-23). The proliferation in vitro and the class I expression of the major histocompatibility complexes of these transduced cells were not different from those of parent cells. T.Tn/IL-21 and T.Tn/IL-23 cells developed small tumors in nude mice, but the tumors regressed spontaneously thereafter in contrast to parent tumors. Expressed IL-21 or IL-23 in human esophageal tumors can produce antitumor effects in a T cell-defective condition.

  • Received September 22, 2003.
  • Accepted December 22, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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Expression of Interleukin-21 and -23 in Human Esophageal Tumors Produced Antitumor Effects in Nude Mice
BAOEN SHAN, LING YU, OSAMU SHIMOZATO, QIAOXIA LI, MASATOSHI TAGAWA
Anticancer Research Jan 2004, 24 (1) 79-82;

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Expression of Interleukin-21 and -23 in Human Esophageal Tumors Produced Antitumor Effects in Nude Mice
BAOEN SHAN, LING YU, OSAMU SHIMOZATO, QIAOXIA LI, MASATOSHI TAGAWA
Anticancer Research Jan 2004, 24 (1) 79-82;
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