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Research ArticleClinical Studies

Differential Expressions of BRCA1 and BRCA2 in Infantile Gynecomastia

DOMINIQUE J. BERNARD-GALLON, PIERRE J. DECHELOTTE, LUDOVIC LE CORRE, NASSERA CHALABI, CECILE VISSAC-SABATIER and YVES-JEAN BIGNON
Anticancer Research January 2004, 24 (1) 321-324;
DOMINIQUE J. BERNARD-GALLON
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PIERRE J. DECHELOTTE
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LUDOVIC LE CORRE
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NASSERA CHALABI
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CECILE VISSAC-SABATIER
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YVES-JEAN BIGNON
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Abstract

BRCA1 and BRCA2 breast cancer susceptibility genes are responsible for most of the hereditary breast cancers. No or very few sporadic breast tumors have been shown to harbor mutations in the coding sequence of BRCA1 or BRCA2. In contrast to normal breast epithelial cells, BRCA1 mRNA levels in tumors appeared to be down-regulated by methylation, while BRCA2 showed significant overexpression in sporadic breast cancers. We report herein an infantile gynecomastia in a two-year-old boy, studied by immunohistochemistry of anti- BRCA1 and anti-BRCA2 antibodies. We demonstrated that BRCA1 proteins, like BRCA2, are widely expressed in the nuclei of epithelial cells surrounding the lumen of the ducts in infantile gynecomastia. The intensive nuclear staining of both proteins in the mammary tissues means that BRCA1 and BRCA2 proteins are largely expressed in infantile gynecomastia.

  • Received November 12, 2003.
  • Accepted December 22, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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Differential Expressions of BRCA1 and BRCA2 in Infantile Gynecomastia
DOMINIQUE J. BERNARD-GALLON, PIERRE J. DECHELOTTE, LUDOVIC LE CORRE, NASSERA CHALABI, CECILE VISSAC-SABATIER, YVES-JEAN BIGNON
Anticancer Research Jan 2004, 24 (1) 321-324;

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Differential Expressions of BRCA1 and BRCA2 in Infantile Gynecomastia
DOMINIQUE J. BERNARD-GALLON, PIERRE J. DECHELOTTE, LUDOVIC LE CORRE, NASSERA CHALABI, CECILE VISSAC-SABATIER, YVES-JEAN BIGNON
Anticancer Research Jan 2004, 24 (1) 321-324;
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