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Research ArticleExperimental Studies

Apoptosis Induced by Oxaliplatin in Human Colon Cancer HCT15 Cell Line

PAOLO MARCHETTI, DOMENICO A.P. GALLA, F. PAOLA RUSSO, ENRICO RICEVUTO, VINCENZO FLATI, GIAMPIERO PORZIO, CORRADO FICORELLA and M. GRAZIA CIFONE
Anticancer Research January 2004, 24 (1) 219-226;
PAOLO MARCHETTI
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DOMENICO A.P. GALLA
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F. PAOLA RUSSO
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ENRICO RICEVUTO
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VINCENZO FLATI
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GIAMPIERO PORZIO
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CORRADO FICORELLA
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M. GRAZIA CIFONE
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Abstract

Background: Oxaliplatin (L-OHP), active in a wide range of human and animal tumours, also CDDP-resistant, possesses unique molecular characteristics of action. However, the mechanisms by which the damage induced by L-OHP triggers a death signal are not yet fully defined. Materials and Methods: After L-OHP treatment of the HCT15 human colon cancer cell line, apoptosis was evaluated by DNA laddering detection and by flow cytometry; the effect on specific caspase-3, -8 and -9 inhibitors, mitochondrial membrane permeability transition, cytochrome C release and expression of CD95 and CD95L were also assessed. Results: HCT15 cells underwent apoptosis when treated with all used drug concentrations (7-25 μM). Treatment of cells with L-OHP resulted in the activation of caspase-8, -9 and -3, in a mitochondrial membrane depolarisation, and in an increase of CD95 receptor and CD95 ligand levels. Conclusion: The results correlated well with the ability of L-OHP to induce apoptosis and give further insights into the mechanisms underlying the L-OHP-induced apoptosis of tumor cells.

  • Received January 7, 2003.
  • Accepted October 30, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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Apoptosis Induced by Oxaliplatin in Human Colon Cancer HCT15 Cell Line
PAOLO MARCHETTI, DOMENICO A.P. GALLA, F. PAOLA RUSSO, ENRICO RICEVUTO, VINCENZO FLATI, GIAMPIERO PORZIO, CORRADO FICORELLA, M. GRAZIA CIFONE
Anticancer Research Jan 2004, 24 (1) 219-226;

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Apoptosis Induced by Oxaliplatin in Human Colon Cancer HCT15 Cell Line
PAOLO MARCHETTI, DOMENICO A.P. GALLA, F. PAOLA RUSSO, ENRICO RICEVUTO, VINCENZO FLATI, GIAMPIERO PORZIO, CORRADO FICORELLA, M. GRAZIA CIFONE
Anticancer Research Jan 2004, 24 (1) 219-226;
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