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Research ArticleExperimental Studies

Potential Antitumor Agents. 34.(1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-b]thiazoles and from Diimidazo[1,2-a:1,2-c]pyrimidine

ALDO ANDREANI, MASSIMILIANO GRANAIOLA, ALBERTO LEONI, ALESSANDRA LOCATELLI, RITA MORIGI, MIRELLA RAMBALDI, GIANLUCA GIORGI and VIDA GARALIENE
Anticancer Research January 2004, 24 (1) 203-212;
ALDO ANDREANI
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MASSIMILIANO GRANAIOLA
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ALBERTO LEONI
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ALESSANDRA LOCATELLI
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RITA MORIGI
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MIRELLA RAMBALDI
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GIANLUCA GIORGI
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VIDA GARALIENE
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Abstract

We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.

  • Received April 18, 2003.
  • Accepted October 10, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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Potential Antitumor Agents. 34.(1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-b]thiazoles and from Diimidazo[1,2-a:1,2-c]pyrimidine
ALDO ANDREANI, MASSIMILIANO GRANAIOLA, ALBERTO LEONI, ALESSANDRA LOCATELLI, RITA MORIGI, MIRELLA RAMBALDI, GIANLUCA GIORGI, VIDA GARALIENE
Anticancer Research Jan 2004, 24 (1) 203-212;

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Potential Antitumor Agents. 34.(1) Synthesis and Antitumor Activity of Guanylhydrazones from Imidazo[2,1-b]thiazoles and from Diimidazo[1,2-a:1,2-c]pyrimidine
ALDO ANDREANI, MASSIMILIANO GRANAIOLA, ALBERTO LEONI, ALESSANDRA LOCATELLI, RITA MORIGI, MIRELLA RAMBALDI, GIANLUCA GIORGI, VIDA GARALIENE
Anticancer Research Jan 2004, 24 (1) 203-212;
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