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Research ArticleExperimental Studies

The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer

ELENA I. SHAGISULTANOVA, INNA A. NOVIKOVA, YURI S. SIDORENKO, GEORGE N. MARCHENKO, ALEX Y. STRONGIN and SERGEI R. MALKHOSYAN
Anticancer Research January 2004, 24 (1) 199-202;
ELENA I. SHAGISULTANOVA
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INNA A. NOVIKOVA
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YURI S. SIDORENKO
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GEORGE N. MARCHENKO
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ALEX Y. STRONGIN
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SERGEI R. MALKHOSYAN
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Abstract

Background: Matrix metalloproteinases (MMPs) contribute in multiple ways to all stages of tumor development, and a number of DNA polymorphisms in the MMP genes are associated with an increased risk of cancer. We previously identified the MMP-21 gene 572C/T polymorphism leading to Ala191Val substitution within the enzyme's catalytic domain. We performed a case-control study to test association between this polymorphism and the risk of breast cancer. Patients and Methods: 572C/T polymorphism was analyzed by RFLP method in 396 unrelated Russian females: 76 breast cancer patients and 320 disease-free blood donors. Results: The frequencies of C/C, T/C and T/T genotypes in patients (69.7%, 25.0% and 5.3%) did not differ significantly form those in controls (61.9%, 34.7% and 3.4%); the polymorphism was not associated with the increased tumor size and the presence of metastases. Conclusion: The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer.

  • Received September 19, 2003.
  • Accepted October 16, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer
ELENA I. SHAGISULTANOVA, INNA A. NOVIKOVA, YURI S. SIDORENKO, GEORGE N. MARCHENKO, ALEX Y. STRONGIN, SERGEI R. MALKHOSYAN
Anticancer Research Jan 2004, 24 (1) 199-202;

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The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer
ELENA I. SHAGISULTANOVA, INNA A. NOVIKOVA, YURI S. SIDORENKO, GEORGE N. MARCHENKO, ALEX Y. STRONGIN, SERGEI R. MALKHOSYAN
Anticancer Research Jan 2004, 24 (1) 199-202;
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