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Research ArticleExperimental Studies

Computational Simulation of Chronic Persistent Virus Infection: Factors Determining Differences in Clinical Outcome of HHV-6, HIV-1 and HTLV-1 Infections Including Aplastic, Hyperplastic and Neoplastic Responses

G.R.F. KRUEGER, M.E. BRANDT, G. WANG and L.M. BUJA
Anticancer Research January 2004, 24 (1) 187-198;
G.R.F. KRUEGER
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M.E. BRANDT
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G. WANG
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L.M. BUJA
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Abstract

A computational model was recently designed to simulate cellular changes in the T cell immune system. The model was validated by simulating cell changes in viral infections which target the same CD4+ T cell, yet cause either hyperplastic, aplastic or neoplastic responses. Respective case material for comparison was available from human infections with human herpesvirus-6 (HHV-6), human immunodeficiency virus (HIV-1) or human T cell leukemia virus (HTLV-1). Starting with cell values for a healthy human individual, factorial changes that influence the individual course of the various infections were determined by an algorithm search procedure. Such factorial differences determining a clinical course with aplasia, hyperplasia or neoplasia are outlined and further discussed in this paper.

  • Received March 31, 2003.
  • Accepted October 13, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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Computational Simulation of Chronic Persistent Virus Infection: Factors Determining Differences in Clinical Outcome of HHV-6, HIV-1 and HTLV-1 Infections Including Aplastic, Hyperplastic and Neoplastic Responses
G.R.F. KRUEGER, M.E. BRANDT, G. WANG, L.M. BUJA
Anticancer Research Jan 2004, 24 (1) 187-198;

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Computational Simulation of Chronic Persistent Virus Infection: Factors Determining Differences in Clinical Outcome of HHV-6, HIV-1 and HTLV-1 Infections Including Aplastic, Hyperplastic and Neoplastic Responses
G.R.F. KRUEGER, M.E. BRANDT, G. WANG, L.M. BUJA
Anticancer Research Jan 2004, 24 (1) 187-198;
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