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Research ArticleExperimental Studies

HIF Transcription Factor Expression and Induction of Hypoxic Response Genes in a Retroperitoneal Angiosarcoma

W. KIMRYN RATHMELL, GEZA ACS, M. CELESTE SIMON and DAVID J. VAUGHN
Anticancer Research January 2004, 24 (1) 167-170;
W. KIMRYN RATHMELL
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GEZA ACS
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M. CELESTE SIMON
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DAVID J. VAUGHN
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Abstract

Angiosarcoma is a rare and highly aggressive tumor of endothelial origin. The molecular mechanisms driving angiosarcoma growth have not been fully elucidated, although autocrine stimulation by vascular endothelial growth factor (VEGF) secretion may play a role in the pathogenesis of this tumor. We identified a patient with a very rare form of angiosarcoma arising from the retroperitoneum. Immunohistochemical analysis demonstrated widespread upregulation of the hypoxic response pathway as a mechanism of enhanced VEGF expression. Disordered regulation of the hypoxic response pathway can result in the expression of factors such as VEGF and erythropoietin, which may promote autocrine tumor growth in angiosarcoma.

  • Received November 10, 2003.
  • Accepted December 16, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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HIF Transcription Factor Expression and Induction of Hypoxic Response Genes in a Retroperitoneal Angiosarcoma
W. KIMRYN RATHMELL, GEZA ACS, M. CELESTE SIMON, DAVID J. VAUGHN
Anticancer Research Jan 2004, 24 (1) 167-170;

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HIF Transcription Factor Expression and Induction of Hypoxic Response Genes in a Retroperitoneal Angiosarcoma
W. KIMRYN RATHMELL, GEZA ACS, M. CELESTE SIMON, DAVID J. VAUGHN
Anticancer Research Jan 2004, 24 (1) 167-170;
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