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Research ArticleExperimental Studies

Numerical Aberrations of Chromosome 17 and the p53 Locus in Small Hepatocellular Carcinomas

HIROSHI YANO, ATSUSHI NANASHIMA, SHIGEKAZU HIDAKA, MASATOSHI HASEBA, KENJI TANAKA, HIROYUKI YAMAGUCHI, TOHRU NAKAGOE, YUTAKA TAGAWA and TAKESHI NAGAYASU
Anticancer Research January 2004, 24 (1) 111-116;
HIROSHI YANO
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ATSUSHI NANASHIMA
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SHIGEKAZU HIDAKA
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MASATOSHI HASEBA
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KENJI TANAKA
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HIROYUKI YAMAGUCHI
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TOHRU NAKAGOE
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YUTAKA TAGAWA
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TAKESHI NAGAYASU
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Abstract

To investigate numerical aberrations of chromosome 17 and the p53 locus in early stages of hepatocellular carcinoma (HCC), 12 fresh-frozen specimens of small HCCs (less than 30 mm in size) were examined by dual-color fluorescence in situ hybridization. We used a chromosome 17 alpha-satellite DNA probe and a p53 locusspecific DNA probe. We also performed immunohistochemical analysis for p53 protein in the same cases. Gain of chromosome 17 was the most frequently observed anomaly, present in 58% of cases, and deletion of the p53 locus was observed in 50% of cases. The combination of chromosome 17 gain and p53 locus deletion was observed in 33.3% of cases. However, overexpression of p53 protein was not observed in any specimens. Our results suggest that gain of chromosome 17 and deletion of the p53 locus could represent early genetic events, prior to overexpression of p53 protein due to mutation, in early stage HCC.

  • Received October 22, 2003.
  • Accepted December 16, 2003.
  • Copyright© 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 24 (1)
Anticancer Research
Vol. 24, Issue 1
January-February 2004
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Numerical Aberrations of Chromosome 17 and the p53 Locus in Small Hepatocellular Carcinomas
HIROSHI YANO, ATSUSHI NANASHIMA, SHIGEKAZU HIDAKA, MASATOSHI HASEBA, KENJI TANAKA, HIROYUKI YAMAGUCHI, TOHRU NAKAGOE, YUTAKA TAGAWA, TAKESHI NAGAYASU
Anticancer Research Jan 2004, 24 (1) 111-116;

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Numerical Aberrations of Chromosome 17 and the p53 Locus in Small Hepatocellular Carcinomas
HIROSHI YANO, ATSUSHI NANASHIMA, SHIGEKAZU HIDAKA, MASATOSHI HASEBA, KENJI TANAKA, HIROYUKI YAMAGUCHI, TOHRU NAKAGOE, YUTAKA TAGAWA, TAKESHI NAGAYASU
Anticancer Research Jan 2004, 24 (1) 111-116;
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