A Scoring System to Predict the Development of Bone Metastasis After Radical Resection of Colorectal Cancer
- ANG LI1,*,
- LUKAS KÄSMANN2,3,*,
- DIRK RADES3 and
- CHUANGANG FU1,2⇑
- 1Department of Colorectal Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, P.R. China
- 2Department of Colorectal Surgery, Shanghai East Hospital, Tongji University, Shanghai, P.R. China
- 3Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
- Correspondence to: Chuangang Fu, Department of Colorectal Surgery, Shanghai East Hospital, Tongji University, Shanghai, P.R. China. Tel: +86 02131166666, e-mail: fugang416{at}126.com
Abstract
Background/Aim: To develop a scoring system to predict bone metastasis after radical resection within 5 years. Patients and Methods: We evaluated the patient records of 1,749 patients, of whom 50 patients developed bone metastasis. Treatment-related factors (age, gender, localization, histology, preoperative carbohydrate antigen 199 level, T-stage, lymph node metastasis (LN) and pulmonary metastasis (PM)) were analyzed. Results: We found three independent risk factors, namely rectal cancer (p=0.038), LN (p=0.006) and metachronous PM (p<0.001). Scoring was conducted by adding zero or one point from each variable and resulted in four groups of 0, 1, 2 or 3 points. Three groups were formed, with 0-1 points vs. 2 points vs. 3 points (1.5% vs. 6.6% and 10.5%, p<0.001). Conclusion: This new score can help clinicians identify patients at risk for continuous monitoring and optimize surveillance to be able to detect and treat bone metastases very early in order to avoid skeletal complications.
- Received July 2, 2017.
- Revision received July 14, 2017.
- Accepted July 17, 2017.
- Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved
