Perioperative Red Blood Cell Transfusion Is Associated with Poor Long-term Survival in Pancreatic Adenocarcinoma

  1. TOSHIO NORIYUKI1,2
  1. 1Department of Surgery, Onomichi General Hospital, Onomichi, Japan
  2. 2Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  3. 3Department of Gastroenterology, Onomichi General Hospital, Onomichi, Japan
  4. 4Department of Pathology, Onomichi General Hospital, Onomichi, Japan
  5. 5Advanced Medical Skill Training Center, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  6. 6Department of Surgery, Medical Corporation Japan Railway Hiroshima Hospital, Hiroshima, Japan
  1. Correspondence to: Hironobu Amano, Department of Surgery, Onomichi General Hospital, Hirahara 1-10-23, Onomichi, Hiroshima, 722-8508 Japan. Tel: +81 848228111, Fax: +81 848233214, e-mail: amanojack{at}star.odn.ne.jp

Abstract

Background/Aim: Perioperative red blood cell transfusion (RBCT) can negatively affect the host's immune system. We investigated the effects of perioperative RBCT on long-term survival among patients with pancreatic ductal adenocarcinoma (PDAC). Patients and Methods: We retrospectively evaluated 148 patients with PDAC who underwent surgery with curative intent (33 who received RBCTs and 115 who did not). Significant prognostic variables on univariate analysis were subjected to multivariate analyses using a Cox proportional hazard regression model. Results: Both groups exhibited significant differences in age, preoperative haemoglobin levels, carbohydrate antigen 19-9 levels, maximum tumour size, tumour staging, operative time, intraoperative blood loss, major vascular resection, and the proportion of pancreaticoduodenectomies performed. Patients who underwent RBCTs exhibited significantly poorer overall survival (p<0.001) and recurrence-free survival (p<0.001) compared to patients who did not. Conclusion: Perioperative RBCT was associated with poorer long-term survival among patients with PDAC who underwent surgery with curative intent.

Footnotes

  • Funding

    None.

  • Conflicts of Interest

    The Authors declare that they have no conflicts of interest.

  • Received August 8, 2017.
  • Revision received August 28, 2017.
  • Accepted August 29, 2017.
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  1. Anticancer Research vol. 37 no. 10 5863-5870
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