Abstract
Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents.
- Bacteria
- cancer
- multidrug resistance
- efflux pumps
- inhibition of efflux pumps
- phenothiazines
- chlorpromazine. thioridazine
- hydantoins
- phenytoin
- SILA 421
- SILA 409
- trifluoromethyl ketones
- review
- Received April 23, 2012.
- Revision received June 11, 2012.
- Accepted June 11, 2012.
- Copyright© 2012 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved