Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein
- HåKAN ANDRÉASSON1,
- ALKWIN WANDERS2,
- XIAO-FENG SUN3,
- ROGER WILLÉN2,
- WILHELM GRAF1,
- PETER NYGREN4,
- BENGT GLIMELIUS4,5,
- ZHI-YONG ZHANG6 and
- HAILE MAHTEME1⇓
- 1Department of Surgical Sciences, Section of Surgery, Uppsala University, Uppsala, Sweden
- 2Department of Immunology, Genetics and Pathology, Section of Oncology, Uppsala University, Uppsala, Sweden
- 3Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden
- 4Department of Radiology, Oncology and Radiation Science, Section of Oncology, Uppsala University, Uppsala, Sweden
- 5Department of Oncology and Pathology, Radiumhemmet, Karolinska Institute, Stockholm, Sweden
- 6Department of Pathology, Tangshan Gongren Hospital, Tangshan, P.R. China
- Correspondence to: Haile Mahteme, MD, Ph.D., Department of Surgery, Uppsala University Hospital, S-751 85 Uppsala, Sweden. Tele: +46 186114613, Fax: +46 18504414, e-mail: Haile.Mahteme{at}surgsci.uu.se
Abstract
Aim: The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP. Materials and Methods: Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables. Results: The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04). Conclusion: The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.
- Received February 10, 2012.
- Revision received March 8, 2012.
- Accepted March 9, 2012.
- Copyright© 2012 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
