A New Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Breast Cancer Susceptibility in Taiwanese Patients
- CHANG-FANG CHIU1,2,3,*,
- HWEI-CHUNG WANG2,4,*,
- CHUNG-HSING WANG2,
- CHENG-LI WANG2,
- CHENG-CHIEH LIN5,
- CHEN-YANG SHEN6,
- SU-YIN CHIANG7 and
- DA-TIAN BAU2,7
- 1Department of Hematology Oncology, China Medical University Hospital, Taichung, Taiwan
- 2Department of Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan
- 3Medical College, China Medical University, Taichung, Taiwan
- 4Department of Comprehensive Breast Service and Surgery, China Medical University Hospital, Taichung, Taiwan
- 5Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
- 6Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, R.O.C.
- 7Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
- Correspondence to: Da-Tian Bau, Ph.D., Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C. Tel: +886422053366, Ext 3312, Fax: +886422053366, Ext 1511, e-mail: datian{at}www.cmuh.org.tw
Abstract
Background: The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. Some new and important polymorphic variants of XRCC4, at codon 247 (rs 3734091), G-1394T (rs 6869366), and Intron 7 (rs 28360317), and their association with breast cancer susceptibility was investigated in a Taiwanese population. Materials and Methods: In a hospital-based case-control study, 432 female patients with breast cancer and 432 age-matched healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped. Results: A significant difference in the frequency of the XRCC4 G-1394T genotype, but not the XRCC4 codon 247, or intron 7 genotypes was found between the breast cancer and control groups. Individuals with G/T or T/T at the XRCC4 G-1394T locus showed a 2.33-fold (95% confidence interval=1.37-3.98) increased risk of breast cancer compared to those with G/G. For XRCC4 codon 247 or intron 7, there was no difference in distribution between the breast cancer and control groups. Conclusion: Our findings suggest that the heterozygous and homozygous T allele of the XRCC4 G-1394T may be associated with the development of breast cancer and may be a useful biomarker for anticancer prevention and intervention.
Footnotes
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↵* Both authors contributed equally to this work.
- Received June 27, 2007.
- Revision received October 25, 2007.
- Accepted November 1, 2007.
- Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
