Abstract
Background/Aim: Exposure to 45% fat diet in utero and during nursing increased body weight and small intestinal tumor numbers in adult F1 multiple intestinal neoplasia (Min/+) mice, implicating that early-life obesogenic conditions predispose for obesity and intestinal tumorigenesis later in life. In this study, it was examined whether these effects were transferred to the next two generations. Results: In F2 mice, exposed to the obesogenic diet as germ cells within the embryonic F1 mice, there were no consistent differences in body weight, blood glucose levels or small intestinal tumor numbers whether their mother or father, both, or no parents were exposed to 45% vs. 10% fat diet. In F3 mice, never exposed to obesogenic diet, no differences were found in any end-points, whether both grandparents were exposed to 45% or 10% fat, or not. Conclusion: The effects of early-life high-fat diet on adult obesity and intestinal tumorigenesis were not inherited transgenera-tionally.
- Received June 3, 2016.
- Revision received June 23, 2016.
- Accepted June 24, 2016.
- Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved