Abstract
Aim: The aim of the present study was to evaluate the feasibility of, and compliance with a regimen using split-dose cisplatin and vinorelbine (split-CV) as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). Patiets and Methods: The treatment schedule included cisplatin at 40 mg/m2 and vinorelbine at 25 mg/m2 administered intravenously on days 1 and 8, every three weeks for four cycles. Results: This study included 22 patients (male/female; 12/10) with a median age of 67 (range 50-76) years; 10 had clinical stage II and 12 stage III; 21 had ECOG 0 and 1 patient ECOG 1; 15 patients had adenocarcinoma, 5 squamous cell and 2 adenosquamous carcinoma; 18 patients had undergone lobectomy, 3 pneumonectomy and 1 segmentectomy. Seventeen out of 22 patients (77%) received the planned 4 cycles. The main adverse events were grade 3/4 neutropenia (76%) and anemia (12%). The average total doses of cisplatin and vinorelbine were 285 mg/m2 and 177 mg/m2, respectively. Conclusion: The split-CV regimen is well-tolerated as adjuvant chemotherapy for completely resected NSCLC.
- Received December 8, 2013.
- Revision received December 24, 2013.
- Accepted December 27, 2013.
- Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved